1ikf

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[[Image:1ikf.gif|left|200px]]
[[Image:1ikf.gif|left|200px]]
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{{Structure
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|PDB= 1ikf |SIZE=350|CAPTION= <scene name='initialview01'>1ikf</scene>, resolution 2.5&Aring;
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The line below this paragraph, containing "STRUCTURE_1ikf", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ABA:ALPHA-AMINOBUTYRIC+ACID'>ABA</scene>, <scene name='pdbligand=BMT:4-METHYL-4-[(E)-2-BUTENYL]-4,N-METHYL-THREONINE'>BMT</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=MLE:N-METHYLLEUCINE'>MLE</scene>, <scene name='pdbligand=MVA:N-METHYLVALINE'>MVA</scene>, <scene name='pdbligand=SAR:SARCOSINE'>SAR</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1ikf| PDB=1ikf | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ikf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ikf OCA], [http://www.ebi.ac.uk/pdbsum/1ikf PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ikf RCSB]</span>
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}}
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'''A CONFORMATION OF CYCLOSPORIN A IN AQUEOUS ENVIRONMENT REVEALED BY THE X-RAY STRUCTURE OF A CYCLOSPORIN-FAB COMPLEX'''
'''A CONFORMATION OF CYCLOSPORIN A IN AQUEOUS ENVIRONMENT REVEALED BY THE X-RAY STRUCTURE OF A CYCLOSPORIN-FAB COMPLEX'''
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==About this Structure==
==About this Structure==
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1IKF is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IKF OCA].
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IKF OCA].
==Reference==
==Reference==
A conformation of cyclosporin A in aqueous environment revealed by the X-ray structure of a cyclosporin-Fab complex., Altschuh D, Vix O, Rees B, Thierry JC, Science. 1992 Apr 3;256(5053):92-4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/1566062 1566062]
A conformation of cyclosporin A in aqueous environment revealed by the X-ray structure of a cyclosporin-Fab complex., Altschuh D, Vix O, Rees B, Thierry JC, Science. 1992 Apr 3;256(5053):92-4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/1566062 1566062]
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[[Category: Protein complex]]
 
[[Category: Altschuh, D.]]
[[Category: Altschuh, D.]]
[[Category: Rees, B.]]
[[Category: Rees, B.]]
[[Category: Thierry, J C.]]
[[Category: Thierry, J C.]]
[[Category: Vix, O.]]
[[Category: Vix, O.]]
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[[Category: complex (antibidy/immunosuppressant)]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:05:57 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:21:00 2008''
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Revision as of 17:05, 2 May 2008

Image:1ikf.gif

Template:STRUCTURE 1ikf

A CONFORMATION OF CYCLOSPORIN A IN AQUEOUS ENVIRONMENT REVEALED BY THE X-RAY STRUCTURE OF A CYCLOSPORIN-FAB COMPLEX


Overview

The conformation of the immunosuppressive drug cyclosporin A (CsA) in a complex with a Fab molecule has been established by crystallographic analysis to 2.65 angstrom resolution. This conformation of CsA is similar to that recently observed in the complex with the rotamase cyclophilin, its binding protein in vivo, and totally different from its conformation in an isolated form as determined from x-ray and nuclear magnetic resonance analysis. Because the surfaces of CsA interacting with cyclophilin or with the Fab are not identical, these results suggest that the conformation of CsA observed in the bound form preexists in aqueous solution and is not produced by interaction with the proteins.

About this Structure

Full crystallographic information is available from OCA.

Reference

A conformation of cyclosporin A in aqueous environment revealed by the X-ray structure of a cyclosporin-Fab complex., Altschuh D, Vix O, Rees B, Thierry JC, Science. 1992 Apr 3;256(5053):92-4. PMID:1566062 Page seeded by OCA on Fri May 2 20:05:57 2008

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