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4em4
From Proteopedia
(Difference between revisions)
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==Crystal Structure of Staphylococcus aureus bound with the covalent inhibitor Pethyl-VS-CoA== | ==Crystal Structure of Staphylococcus aureus bound with the covalent inhibitor Pethyl-VS-CoA== | ||
| - | <StructureSection load='4em4' size='340' side='right' caption='[[4em4]], [[Resolution|resolution]] 1.82Å' scene=''> | + | <StructureSection load='4em4' size='340' side='right'caption='[[4em4]], [[Resolution|resolution]] 1.82Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4em4]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4em4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_USA300 Staphylococcus aureus subsp. aureus USA300]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EM4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EM4 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA8:[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]+[(3R)-2,2-dimethyl-3-oxidanyl-4-oxidanylidene-4-[[3-oxidanylidene-3-[4-(phenylsulfonyl)butylamino]propyl]amino]butyl]+hydrogen+phosphate'>CA8</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA8:[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]+[(3R)-2,2-dimethyl-3-oxidanyl-4-oxidanylidene-4-[[3-oxidanylidene-3-[4-(phenylsulfonyl)butylamino]propyl]amino]butyl]+hydrogen+phosphate'>CA8</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4em4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4em4 OCA], [https://pdbe.org/4em4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4em4 RCSB], [https://www.ebi.ac.uk/pdbsum/4em4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4em4 ProSAT]</span></td></tr> | |
| - | + | ||
| - | + | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/CDR_STAA3 CDR_STAA3]] Catalyzes specifically the NADPH-dependent reduction of coenzyme A disulfide.[HAMAP-Rule:MF_01608] |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</div> | </div> | ||
<div class="pdbe-citations 4em4" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 4em4" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Coenzyme A-Disulfide Reductase|Coenzyme A-Disulfide Reductase]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Staphylococcus aureus subsp. aureus USA300]] |
| - | [[Category: Claiborne | + | [[Category: Claiborne A]] |
| - | [[Category: Edwards | + | [[Category: Edwards JS]] |
| - | [[Category: Redinbo | + | [[Category: Redinbo MR]] |
| - | [[Category: Wallace | + | [[Category: Wallace BD]] |
| - | + | ||
Current revision
Crystal Structure of Staphylococcus aureus bound with the covalent inhibitor Pethyl-VS-CoA
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