1iko

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[[Image:1iko.gif|left|200px]]
[[Image:1iko.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1iko |SIZE=350|CAPTION= <scene name='initialview01'>1iko</scene>, resolution 1.92&Aring;
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The line below this paragraph, containing "STRUCTURE_1iko", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= ephrin-B2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
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|DOMAIN=
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{{STRUCTURE_1iko| PDB=1iko | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1iko FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1iko OCA], [http://www.ebi.ac.uk/pdbsum/1iko PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1iko RCSB]</span>
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}}
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'''CRYSTAL STRUCTURE OF THE MURINE EPHRIN-B2 ECTODOMAIN'''
'''CRYSTAL STRUCTURE OF THE MURINE EPHRIN-B2 ECTODOMAIN'''
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[[Category: Harrison, C J.]]
[[Category: Harrison, C J.]]
[[Category: Toth, J.]]
[[Category: Toth, J.]]
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[[Category: glycosylation]]
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[[Category: Glycosylation]]
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[[Category: greek key]]
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[[Category: Greek key]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:06:24 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:21:08 2008''
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Revision as of 17:06, 2 May 2008

Image:1iko.gif

Template:STRUCTURE 1iko

CRYSTAL STRUCTURE OF THE MURINE EPHRIN-B2 ECTODOMAIN


Overview

Eph receptor tyrosine kinases and their membrane-associated ligands, the ephrins, are essential regulators of axon guidance, cell migration, segmentation, and angiogenesis. There are two classes of vertebrate ephrin ligands which have distinct binding specificities for their cognate receptors. Multimerization of the ligands is required for receptor activation, and ephrin ligands themselves signal intracellularly upon binding Eph receptors. We have determined the structure of the extracellular domain of mouse ephrin-B2. The ephrin ectodomain is an eight-stranded beta barrel with topological similarity to plant nodulins and phytocyanins. Based on the structure, we have identified potential surface determinants of Eph/ephrin binding specificity and a ligand dimerization region. The high sequence similarity among ephrin ectodomains indicates that all ephrins may be modeled upon the ephrin-B2 structure presented here.

About this Structure

1IKO is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Crystal structure of an ephrin ectodomain., Toth J, Cutforth T, Gelinas AD, Bethoney KA, Bard J, Harrison CJ, Dev Cell. 2001 Jul;1(1):83-92. PMID:11703926 Page seeded by OCA on Fri May 2 20:06:24 2008

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