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4eox
From Proteopedia
(Difference between revisions)
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==X-ray Structure of Polypeptide Deformylase Bound to a Acylprolinamide inhibitor== | ==X-ray Structure of Polypeptide Deformylase Bound to a Acylprolinamide inhibitor== | ||
| - | <StructureSection load='4eox' size='340' side='right' caption='[[4eox]], [[Resolution|resolution]] 1.78Å' scene=''> | + | <StructureSection load='4eox' size='340' side='right'caption='[[4eox]], [[Resolution|resolution]] 1.78Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4eox]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4eox]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae_R6 Streptococcus pneumoniae R6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EOX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EOX FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0S5:N-BENZOYL-1-[(2R)-3-CYCLOPENTYL-2-{[FORMYL(HYDROXY)AMINO]METHYL}PROPANOYL]-L-PROLINAMIDE'>0S5</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0S5:N-BENZOYL-1-[(2R)-3-CYCLOPENTYL-2-{[FORMYL(HYDROXY)AMINO]METHYL}PROPANOYL]-L-PROLINAMIDE'>0S5</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4eox FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eox OCA], [https://pdbe.org/4eox PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4eox RCSB], [https://www.ebi.ac.uk/pdbsum/4eox PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4eox ProSAT]</span></td></tr> | |
| - | + | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/DEF_STRR6 DEF_STRR6]] Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity). |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Streptococcus pneumoniae R6]] |
| - | [[Category: Campobasso | + | [[Category: Campobasso N]] |
| - | [[Category: Ward | + | [[Category: Ward P]] |
| - | + | ||
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Revision as of 07:21, 28 September 2022
X-ray Structure of Polypeptide Deformylase Bound to a Acylprolinamide inhibitor
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