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4eq1

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==Crystal Structure of the ARNT PAS-B homodimer==
==Crystal Structure of the ARNT PAS-B homodimer==
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<StructureSection load='4eq1' size='340' side='right' caption='[[4eq1]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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<StructureSection load='4eq1' size='340' side='right'caption='[[4eq1]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4eq1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EQ1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EQ1 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4eq1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EQ1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EQ1 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PE5:3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL'>PE5</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PE5:3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL'>PE5</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1x0o|1x0o]], [[2hv1|2hv1]], [[2k7s|2k7s]], [[2b02|2b02]], [[3f1p|3f1p]], [[3f1o|3f1o]], [[3h7w|3h7w]], [[3h82|3h82]], [[3f1n|3f1n]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4eq1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eq1 OCA], [https://pdbe.org/4eq1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4eq1 RCSB], [https://www.ebi.ac.uk/pdbsum/4eq1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4eq1 ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ARNT, BHLHE2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4eq1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eq1 OCA], [http://pdbe.org/4eq1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4eq1 RCSB], [http://www.ebi.ac.uk/pdbsum/4eq1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4eq1 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ARNT_HUMAN ARNT_HUMAN]] Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia.
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[[https://www.uniprot.org/uniprot/ARNT_HUMAN ARNT_HUMAN]] Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4eq1" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4eq1" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[3D structures of hypoxia-inducible factor|3D structures of hypoxia-inducible factor]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Gardner, K H]]
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[[Category: Large Structures]]
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[[Category: Key, J M]]
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[[Category: Gardner KH]]
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[[Category: Ahr]]
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[[Category: Key JM]]
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[[Category: Dna-binding]]
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[[Category: Hif1]]
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[[Category: Hif2]]
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[[Category: Homodimer]]
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[[Category: Per-arnt-sim]]
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[[Category: Transcription]]
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[[Category: Transcription factor]]
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[[Category: Transcription regulation]]
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Revision as of 07:22, 28 September 2022

Crystal Structure of the ARNT PAS-B homodimer

PDB ID 4eq1

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