We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.
Biosynthesis of cholesterol
From Proteopedia
(Difference between revisions)
| Line 2: | Line 2: | ||
Synthesis within the body starts with the mevalonate pathway where two molecules of acetyl CoA condense to form acetoacetyl-CoA. This is followed by a second condensation between acetyl CoA and acetoacetyl-CoA to form 3-hydroxy-3-methylglutaryl CoA (HMG-CoA). This molecule is then reduced to mevalonate by the enzyme [[HMG-CoA reductase]]. Production of mevalonate is the rate-limiting and irreversible step in cholesterol synthesis and is the site of action for statins. | Synthesis within the body starts with the mevalonate pathway where two molecules of acetyl CoA condense to form acetoacetyl-CoA. This is followed by a second condensation between acetyl CoA and acetoacetyl-CoA to form 3-hydroxy-3-methylglutaryl CoA (HMG-CoA). This molecule is then reduced to mevalonate by the enzyme [[HMG-CoA reductase]]. Production of mevalonate is the rate-limiting and irreversible step in cholesterol synthesis and is the site of action for statins. | ||
| - | '''Step 1 Acetoacetyl-CoA thiolase | + | '''Mevalonate pathway''' |
| + | |||
| + | ''Step 1 Acetoacetyl-CoA thiolase'' | ||
*[[Acetoacetyl-CoA thiolase]] | *[[Acetoacetyl-CoA thiolase]] | ||
Revision as of 12:20, 29 September 2022
| |||||||||||
