1il6

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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1il6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1il6 OCA], [http://www.ebi.ac.uk/pdbsum/1il6 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1il6 RCSB]</span>
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'''HUMAN INTERLEUKIN-6, NMR, MINIMIZED AVERAGE STRUCTURE'''
'''HUMAN INTERLEUKIN-6, NMR, MINIMIZED AVERAGE STRUCTURE'''
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[[Category: Xu, G Y.]]
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[[Category: Yu, H A.]]
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[[Category: cytokine]]
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[[Category: Cytokine]]
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[[Category: glycoprotein]]
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[[Category: Glycoprotein]]
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[[Category: growth factor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:07:14 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:21:17 2008''
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Revision as of 17:07, 2 May 2008

Image:1il6.jpg

Template:STRUCTURE 1il6

HUMAN INTERLEUKIN-6, NMR, MINIMIZED AVERAGE STRUCTURE


Overview

Interleukin-6 (IL-6) is a 185 amino acid cytokine which exerts multiple biological effects in vivo and whose dysregulation underlies several disease processes. The solution structure of recombinant human interleukin-6 has now been determined using heteronuclear three and four-dimensional NMR spectroscopy. The structure of the molecule was determined using 3044 distance and torsion restraints derived by NMR spectroscopy to generate an ensemble of 32 structures using a combined distance geometry/simulated annealing protocol. The protein contains five alpha-helices interspersed with variable-length loops; four of these helices constitute a classical four-helix bundle with the fifth helix located in the CD loop. There were no distance violations greater than 0.3 A in any of the final 32 structures and the ensemble has an average-to-the-mean backbone root-mean-square deviation of 0.50 A for the core four-helix bundle. Although the amino-terminal 19 amino acids are disordered in solution, the remainder of the molecule has a well defined structure that shares many features displayed by other long-chain four-helix bundle cytokines. The high-resolution NMR structure of hIL-6 is used to rationalize available mutagenesis data in terms of a heteromeric receptor complex.

About this Structure

1IL6 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Solution structure of recombinant human interleukin-6., Xu GY, Yu HA, Hong J, Stahl M, McDonagh T, Kay LE, Cumming DA, J Mol Biol. 1997 May 2;268(2):468-81. PMID:9159484 Page seeded by OCA on Fri May 2 20:07:14 2008

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