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Biosynthesis of cholesterol

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'''Mevalonate pathway'''
'''Mevalonate pathway'''
-
''Step 1 Acetoacetyl-CoA thiolase''
+
''Acetoacetyl-CoA thiolase''
*[[Acetoacetyl-CoA thiolase]]
*[[Acetoacetyl-CoA thiolase]]
-
''Step 2 hydroxymethylglutaryl-CoA synthase or HMG-CoA synthase; EC 2.3.3.10''
+
''hydroxymethylglutaryl-CoA synthase or HMG-CoA synthase; EC 2.3.3.10''
*[[1xpk]]
*[[1xpk]]
-
''Step 3 HMG-CoA Reductase''
+
''HMG-CoA Reductase''
*[[HMG-CoA Reductase]]
*[[HMG-CoA Reductase]]
-
''Step 4 Mevalonate kinase''
+
''Mevalonate kinase''
*[[Mevalonate kinase]]
*[[Mevalonate kinase]]
-
''Step 5 Phosphomevalonate kinase''
+
''Phosphomevalonate kinase''
*The Crystal Structure of Human Phosphomavelonate Kinase At 1.8 A Resolution [[3ch4]]
*The Crystal Structure of Human Phosphomavelonate Kinase At 1.8 A Resolution [[3ch4]]
-
''Step 6 Mevalonate-5-pyrophosphate decarboxylase''
+
''Mevalonate-5-pyrophosphate decarboxylase''
Diphosphomevalonate decarboxylase (EC 4.1.1.33), most commonly referred to in scientific literature as mevalonate diphosphate decarboxylase.
Diphosphomevalonate decarboxylase (EC 4.1.1.33), most commonly referred to in scientific literature as mevalonate diphosphate decarboxylase.
*[[Sandbox Reserved 333|Mevalonate Diphosphate Decarboxylase]]
*[[Sandbox Reserved 333|Mevalonate Diphosphate Decarboxylase]]
 +
 +
''Isopentenyl pyrophosphate isomerase''
 +
 +
Isopentenyl pyrophosphate isomerase (EC 5.3.3.2, IPP isomerase), also known as Isopentenyl-diphosphate delta isomerase
 +
 +
*[[Isopentenyl-diphosphate delta-isomerase]]
</StructureSection>
</StructureSection>
== References ==
== References ==
<references/>
<references/>

Revision as of 14:00, 2 October 2022

Crystal Structure of HMG-CoA, (PDB code 1dq8)

Drag the structure with the mouse to rotate

References

Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky

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