Mevalonate pathway

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Revision as of 13:48, 2 October 2022 (edit) Alexander Berchansky (Talk | contribs) (Redirecting to Biosynthesis of cholesterol) ← Previous diff		Revision as of 11:06, 3 October 2022 (edit) (undo) Alexander Berchansky (Talk | contribs) Next diff →
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-	#REDIRECT [[Biosynthesis of cholesterol]]	+	Production of mevalonate is the rate-limiting and irreversible step in cholesterol synthesis and is the site of action for statins.
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		+	Acetyl-CoA is coming from [[Citric Acid Cycle]].
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		+	'''Mevalonate pathway'''
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		+	''Acetoacetyl-CoA thiolase''
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		+	*[[Acetoacetyl-CoA thiolase]]
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		+	''Hydroxymethylglutaryl-CoA synthase or HMG-CoA synthase; EC 2.3.3.10''
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		+	*[[1xpk]]
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		+	''HMG-CoA Reductase''
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		+	*[[HMG-CoA Reductase]]
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		+	''Mevalonate kinase''
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		+	*[[Mevalonate kinase]]
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		+	''Phosphomevalonate kinase''
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		+	*The Crystal Structure of Human Phosphomavelonate Kinase At 1.8 A Resolution [[3ch4]]
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		+	''Mevalonate-5-pyrophosphate decarboxylase''
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		+	Diphosphomevalonate decarboxylase (EC 4.1.1.33), most commonly referred to in scientific literature as mevalonate diphosphate decarboxylase.
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		+	*[[Sandbox Reserved 333|Mevalonate Diphosphate Decarboxylase]]
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		+	''Isopentenyl pyrophosphate isomerase''
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		+	Isopentenyl pyrophosphate isomerase (EC 5.3.3.2, IPP isomerase), also known as Isopentenyl-diphosphate delta isomerase
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		+	*[[Isopentenyl-diphosphate delta-isomerase]]
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		+	Mevalonate is finally converted to isopentenyl pyrophosphate.

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Revision as of 11:06, 3 October 2022

Production of mevalonate is the rate-limiting and irreversible step in cholesterol synthesis and is the site of action for statins.

Acetyl-CoA is coming from Citric Acid Cycle.

Mevalonate pathway

Acetoacetyl-CoA thiolase

• Acetoacetyl-CoA thiolase

Hydroxymethylglutaryl-CoA synthase or HMG-CoA synthase; EC 2.3.3.10

• 1xpk

HMG-CoA Reductase

• HMG-CoA Reductase

Mevalonate kinase

• Mevalonate kinase

Phosphomevalonate kinase

• The Crystal Structure of Human Phosphomavelonate Kinase At 1.8 A Resolution 3ch4

Mevalonate-5-pyrophosphate decarboxylase

Diphosphomevalonate decarboxylase (EC 4.1.1.33), most commonly referred to in scientific literature as mevalonate diphosphate decarboxylase.

• Mevalonate Diphosphate Decarboxylase

Isopentenyl pyrophosphate isomerase

Isopentenyl pyrophosphate isomerase (EC 5.3.3.2, IPP isomerase), also known as Isopentenyl-diphosphate delta isomerase

• Isopentenyl-diphosphate delta-isomerase

Mevalonate is finally converted to isopentenyl pyrophosphate.