4f1t

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==Crystal Structure of the Roco4 Kinase Domain from D. discoideum bound to the ROCK Inhibitor H1152==
==Crystal Structure of the Roco4 Kinase Domain from D. discoideum bound to the ROCK Inhibitor H1152==
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<StructureSection load='4f1t' size='340' side='right' caption='[[4f1t]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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<StructureSection load='4f1t' size='340' side='right'caption='[[4f1t]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4f1t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_11735 Atcc 11735]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F1T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4F1T FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4f1t]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Dictyostelium_discoideum Dictyostelium discoideum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F1T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4F1T FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=H52:(S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]-HOMOPIPERAZINE'>H52</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=H52:(S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]-HOMOPIPERAZINE'>H52</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4f0f|4f0f]], [[4f0g|4f0g]], [[4f1m|4f1m]], [[4f1o|4f1o]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4f1t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f1t OCA], [https://pdbe.org/4f1t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4f1t RCSB], [https://www.ebi.ac.uk/pdbsum/4f1t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4f1t ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DDB_G0288251, roco4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=44689 ATCC 11735])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4f1t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f1t OCA], [http://pdbe.org/4f1t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4f1t RCSB], [http://www.ebi.ac.uk/pdbsum/4f1t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4f1t ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ROCO4_DICDI ROCO4_DICDI]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Serine/threonine protein kinase|Serine/threonine protein kinase]]
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*[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Atcc 11735]]
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[[Category: Dictyostelium discoideum]]
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[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: Large Structures]]
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[[Category: Gilsbach, B K]]
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[[Category: Gilsbach BK]]
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[[Category: Kortholt, A]]
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[[Category: Kortholt A]]
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[[Category: Vetter, I R]]
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[[Category: Vetter IR]]
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[[Category: Wittinghofer, A]]
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[[Category: Wittinghofer A]]
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[[Category: Atp-binding]]
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[[Category: Kinase]]
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[[Category: Lrrk2]]
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[[Category: Nucleotide-binding]]
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[[Category: Protein kinase]]
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[[Category: Roco]]
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[[Category: Serine/threonine-protein kinase]]
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[[Category: Signaling protein]]
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[[Category: Signaling protein-inhibitor complex]]
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[[Category: Transferase]]
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Revision as of 04:28, 7 October 2022

Crystal Structure of the Roco4 Kinase Domain from D. discoideum bound to the ROCK Inhibitor H1152

PDB ID 4f1t

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