1h07
From Proteopedia
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Revision as of 15:04, 12 November 2007
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CDK2 IN COMPLEX WITH A DISUBSTITUTED 4, 6-BIS ANILINO PYRIMIDINE CDK4 INHIBITOR
Overview
Using a high-throughput screening campaign, we identified the 4,6-bis, anilino pyrimidines as inhibitors of the cyclin-dependent kinase, CDK4., Herein we describe the further chemical modification and use of X-ray, crystallography to develop potent and selective in vitro inhibitors of, CDK4.
About this Structure
1H07 is a Single protein structure of sequence from Homo sapiens with ACE and MFP as ligands. Active as Transferred entry: 2.7.11.1, with EC number 2.7.1.37 Structure known Active Site: MFP. Full crystallographic information is available from OCA.
Reference
Cyclin-dependent kinase 4 inhibitors as a treatment for cancer. Part 1: identification and optimisation of substituted 4,6-bis anilino pyrimidines., Beattie JF, Breault GA, Ellston RP, Green S, Jewsbury PJ, Midgley CJ, Naven RT, Minshull CA, Pauptit RA, Tucker JA, Pease JE, Bioorg Med Chem Lett. 2003 Sep 15;13(18):2955-60. PMID:12941311
Page seeded by OCA on Mon Nov 12 17:11:03 2007
Categories: Homo sapiens | Single protein | Transferred entry: 2.7.11.1 | Beattie, J.F. | Breault, G.A. | Ellston, R.P.A. | Green, S. | Jewsbury, P.J. | Midgley, C.J. | Minshull, C.A. | Naven, R.T. | Pauptit, R.A. | Pease, J.E. | Tucker, J.A. | ACE | MFP | Mitosis | Serine/threonine-protein kinase | Transferase
