1inr

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[[Image:1inr.jpg|left|200px]]
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{{Structure
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1inr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1inr OCA], [http://www.ebi.ac.uk/pdbsum/1inr PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1inr RCSB]</span>
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'''CYTOKINE SYNTHESIS'''
'''CYTOKINE SYNTHESIS'''
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[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Walter, M R.]]
[[Category: Walter, M R.]]
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[[Category: cytokine]]
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[[Category: Cytokine]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:11:50 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:22:19 2008''
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Revision as of 17:11, 2 May 2008

Image:1inr.jpg

Template:STRUCTURE 1inr

CYTOKINE SYNTHESIS


Overview

The crystal structure of recombinant human interleukin 10 (rhIL-10) has been determined by X-ray crystallography at 2.0 A resolution. Interleukin 10 is a dimer composed of identical polypeptide chains related by a 2-fold axis. The molecule is predominantly alpha-helical. The main-chain fold resembles that of interferon gamma (IFN-gamma) in which the structural integrity of each domain is dependent on the intertwining of helices from each peptide chain. Comparison of rhIL-10 and IFN-gamma reveals differences in helix lengths and orientations of the 2-fold related domains. Interleukin 10 and IFN-gamma contain several conserved residues in their internal cores which suggest a possible "fingerprint" for detection of other members of this fold.

About this Structure

1INR is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of interleukin 10 reveals an interferon gamma-like fold., Walter MR, Nagabhushan TL, Biochemistry. 1995 Sep 26;34(38):12118-25. PMID:7547951 Page seeded by OCA on Fri May 2 20:11:50 2008

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