1ioj
From Proteopedia
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[[Image:1ioj.gif|left|200px]] | [[Image:1ioj.gif|left|200px]] | ||
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'''HUMAN APOLIPOPROTEIN C-I, NMR, 18 STRUCTURES''' | '''HUMAN APOLIPOPROTEIN C-I, NMR, 18 STRUCTURES''' | ||
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[[Category: Sparrow, J T.]] | [[Category: Sparrow, J T.]] | ||
[[Category: Weisgraber, K H.]] | [[Category: Weisgraber, K H.]] | ||
| - | [[Category: | + | [[Category: Amphipathic helix]] |
| - | [[Category: | + | [[Category: Apolipoprotein]] |
| - | [[Category: | + | [[Category: Lcat activation]] |
| - | [[Category: | + | [[Category: Lipid association]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:13:32 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 17:13, 2 May 2008
HUMAN APOLIPOPROTEIN C-I, NMR, 18 STRUCTURES
Overview
Apolipoprotein (apo) C-I is a 57-residue exchangeable plasma protein distributed mainly in high and very low density lipoprotein. In this report we present the nuclear magnetic resonance spectra of native apoC-I and synthetic apoC-I, containing selected 15N-labelled amino acids, in the presence of sodium dodecyl sulfate. The proton resonances of apoC-I are assigned and the secondary structure is estimated from the difference of measured alpha-proton chemical shifts to random coil values and the observed NOE interactions. According to these data apoC-I forms two helices, Val-4-Lys-30 and Leu-34-Lys-52, linked by an unstructured region Gln-31-Glu-33. The N-terminal segments of each helix, Val-4-Gly-15 and Leu-34-Met-38, appear to be more flexible than the helical core regions Asn-16-Lys-30 and Arg-39-Lys-52.
About this Structure
1IOJ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Sequence-specific 1H NMR resonance assignments and secondary structure of human apolipoprotein C-I in the presence of sodium dodecyl sulfate., Rozek A, Sparrow JT, Weisgraber KH, Cushley RJ, Biochem Cell Biol. 1998;76(2-3):267-75. PMID:9923695 Page seeded by OCA on Fri May 2 20:13:32 2008
