1h2p

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Revision as of 15:05, 12 November 2007

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spinqualitylabelsall models 1h2p, resolution 2.8Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

HUMAN CD55 DOMAINS 3 & 4

Contents 1 Overview 2 Disease 3 About this Structure 4 Reference

Overview

Decay-accelerating factor (CD55), a regulator of the alternative and, classical pathways of complement activation, is expressed on all, serum-exposed cells. It is used by pathogens, including many enteroviruses, and uropathogenic Escherichia coli, as a receptor prior to infection. We, describe the x-ray structure of a pathogen-binding fragment of human CD55, at 1.7 A resolution containing two of the three domains required for, regulation of human complement. We have used mutagenesis to map biological, functions onto the molecule; decay-accelerating activity maps to a single, face of the molecule, whereas bacterial and viral pathogens recognize a, variety of different sites on CD55.

Disease

Known diseases associated with this structure: Blood group Cromer OMIM:[125240], Blood group, Knops system OMIM:[120620], CR1 deficiency OMIM:[120620], Malaria, severe, resistance to OMIM:[120620], SLE susceptibility OMIM:[120620]

About this Structure

1H2P is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Mapping CD55 function. The structure of two pathogen-binding domains at 1.7 A., Williams P, Chaudhry Y, Goodfellow IG, Billington J, Powell R, Spiller OB, Evans DJ, Lea S, J Biol Chem. 2003 Mar 21;278(12):10691-6. Epub 2002 Dec 22. PMID:12499389

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