6vwb
From Proteopedia
(Difference between revisions)
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<StructureSection load='6vwb' size='340' side='right'caption='[[6vwb]]' scene=''> | <StructureSection load='6vwb' size='340' side='right'caption='[[6vwb]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full | + | <table><tr><td colspan='2'>[[6vwb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VWB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6VWB FirstGlance]. <br> |
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6vwb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vwb OCA], [https://pdbe.org/6vwb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6vwb RCSB], [https://www.ebi.ac.uk/pdbsum/6vwb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6vwb ProSAT]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6vwb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vwb OCA], [https://pdbe.org/6vwb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6vwb RCSB], [https://www.ebi.ac.uk/pdbsum/6vwb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6vwb ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/MUS81_HUMAN MUS81_HUMAN] Interacts with EME1 and EME2 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks.<ref>PMID:11741546</ref> <ref>PMID:12374758</ref> <ref>PMID:12686547</ref> <ref>PMID:12721304</ref> <ref>PMID:14617801</ref> <ref>PMID:15805243</ref> <ref>PMID:17289582</ref> <ref>PMID:19595721</ref> <ref>PMID:19596235</ref> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Endonuclease 3D structures|Endonuclease 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Arrowsmith CH]] | [[Category: Arrowsmith CH]] | ||
Current revision
Solution structure of the N-terminal helix-hairpin-helix domain of human MUS81
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