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4fl6

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==Crystal structure of the complex of the 3-MBT repeat domain of L3MBTL3 and UNC1215==
==Crystal structure of the complex of the 3-MBT repeat domain of L3MBTL3 and UNC1215==
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<StructureSection load='4fl6' size='340' side='right' caption='[[4fl6]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
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<StructureSection load='4fl6' size='340' side='right'caption='[[4fl6]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4fl6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FL6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FL6 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4fl6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FL6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FL6 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=UWN:[2-(PHENYLAMINO)BENZENE-1,4-DIYL]BIS{[4-(PYRROLIDIN-1-YL)PIPERIDIN-1-YL]METHANONE}'>UWN</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=UWN:[2-(PHENYLAMINO)BENZENE-1,4-DIYL]BIS{[4-(PYRROLIDIN-1-YL)PIPERIDIN-1-YL]METHANONE}'>UWN</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">KIAA1798, L3MBTL3, MBT1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fl6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fl6 OCA], [https://pdbe.org/4fl6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fl6 RCSB], [https://www.ebi.ac.uk/pdbsum/4fl6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fl6 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fl6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fl6 OCA], [http://pdbe.org/4fl6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4fl6 RCSB], [http://www.ebi.ac.uk/pdbsum/4fl6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4fl6 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/LMBL3_HUMAN LMBL3_HUMAN]] Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Required for normal maturation of myeloid progenitor cells (By similarity).
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[https://www.uniprot.org/uniprot/LMBL3_HUMAN LMBL3_HUMAN] Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Required for normal maturation of myeloid progenitor cells (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C H]]
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[[Category: Large Structures]]
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[[Category: Bountra, C]]
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[[Category: Arrowsmith CH]]
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[[Category: Brown, P J]]
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[[Category: Bountra C]]
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[[Category: Dong, A]]
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[[Category: Brown PJ]]
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[[Category: Edwards, A M]]
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[[Category: Dong A]]
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[[Category: Frye, S V]]
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[[Category: Edwards AM]]
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[[Category: Graslund, S]]
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[[Category: Frye SV]]
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[[Category: Ingerman, L A]]
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[[Category: Graslund S]]
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[[Category: Ravichandran, M]]
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[[Category: Ingerman LA]]
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[[Category: Structural genomic]]
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[[Category: Ravichandran M]]
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[[Category: Tempel, W]]
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[[Category: Tempel W]]
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[[Category: Zhong, N]]
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[[Category: Zhong N]]
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[[Category: Chromatin modification]]
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[[Category: Mbt repeat]]
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[[Category: Sgc]]
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[[Category: Transcription]]
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[[Category: Transcription repression]]
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Revision as of 19:55, 19 October 2022

Crystal structure of the complex of the 3-MBT repeat domain of L3MBTL3 and UNC1215

PDB ID 4fl6

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