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4fmk

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==Crystal structure of mouse nectin-2 extracellular fragment D1-D2==
==Crystal structure of mouse nectin-2 extracellular fragment D1-D2==
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<StructureSection load='4fmk' size='340' side='right' caption='[[4fmk]], [[Resolution|resolution]] 2.56&Aring;' scene=''>
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<StructureSection load='4fmk' size='340' side='right'caption='[[4fmk]], [[Resolution|resolution]] 2.56&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4fmk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FMK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FMK FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4fmk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FMK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FMK FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4fmf|4fmf]], [[4fn0|4fn0]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fmk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fmk OCA], [https://pdbe.org/4fmk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fmk RCSB], [https://www.ebi.ac.uk/pdbsum/4fmk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fmk ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Pvrl2, Mph, Pvr, Pvs ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fmk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fmk OCA], [http://pdbe.org/4fmk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4fmk RCSB], [http://www.ebi.ac.uk/pdbsum/4fmk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4fmk ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PVRL2_MOUSE PVRL2_MOUSE]] Probable cell adhesion protein.
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[https://www.uniprot.org/uniprot/NECT2_MOUSE NECT2_MOUSE] Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive. Probable cell adhesion protein.[UniProtKB:Q92692]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4fmk" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4fmk" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Poliovirus receptor-related protein|Poliovirus receptor-related protein]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Lk3 transgenic mice]]
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[[Category: Large Structures]]
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[[Category: Brasch, J]]
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[[Category: Mus musculus]]
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[[Category: Harrison, O J]]
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[[Category: Brasch J]]
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[[Category: Shapiro, L]]
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[[Category: Harrison OJ]]
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[[Category: Cell adhesion]]
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[[Category: Shapiro L]]
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[[Category: Ig domain]]
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[[Category: Immunoglobulin-like domain]]
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[[Category: Viral entry receptor]]
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Revision as of 19:58, 19 October 2022

Crystal structure of mouse nectin-2 extracellular fragment D1-D2

PDB ID 4fmk

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