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4fqo

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<StructureSection load='4fqo' size='340' side='right'caption='[[4fqo]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
<StructureSection load='4fqo' size='340' side='right'caption='[[4fqo]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4fqo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FQO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FQO FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4fqo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FQO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FQO FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AZ3:4,4-[HEPTANE-1,7-DIYLBIS(OXY)]DIBENZENECARBOXIMIDAMIDE'>AZ3</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AZ3:4,4-[HEPTANE-1,7-DIYLBIS(OXY)]DIBENZENECARBOXIMIDAMIDE'>AZ3</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3cr4|3cr4]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fqo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fqo OCA], [https://pdbe.org/4fqo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fqo RCSB], [https://www.ebi.ac.uk/pdbsum/4fqo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fqo ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fqo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fqo OCA], [http://pdbe.org/4fqo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4fqo RCSB], [http://www.ebi.ac.uk/pdbsum/4fqo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4fqo ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/S100B_BOVIN S100B_BOVIN]] Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization (By similarity).<ref>PMID:14661952</ref>
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[https://www.uniprot.org/uniprot/S100B_BOVIN S100B_BOVIN] Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization (By similarity).<ref>PMID:14661952</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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[[Category: Bos taurus]]
[[Category: Bos taurus]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Bezawada, P]]
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[[Category: Bezawada P]]
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[[Category: Coop, A]]
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[[Category: Coop A]]
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[[Category: Hartman, K G]]
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[[Category: Hartman KG]]
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[[Category: Kudrimoti, S]]
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[[Category: Kudrimoti S]]
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[[Category: MacKerrell, A D]]
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[[Category: MacKerrell AD]]
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[[Category: McKnight, L E]]
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[[Category: McKnight LE]]
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[[Category: Raman, E P]]
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[[Category: Raman EP]]
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[[Category: Toth, E A]]
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[[Category: Toth EA]]
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[[Category: Weber, D J]]
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[[Category: Weber DJ]]
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[[Category: Wilder, P T]]
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[[Category: Wilder PT]]
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[[Category: Calcium binding protein]]
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[[Category: Ef-hand protein]]
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[[Category: Protein binding-inhibitor complex]]
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[[Category: Protein-inhibitor complex]]
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Revision as of 20:06, 19 October 2022

Crystal Structure of Calcium-Loaded S100B Bound to SBi4211

PDB ID 4fqo

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