4fsj

<StructureSection load='4fsj' size='340' side='right' caption='[[4fsj]], [[Resolution|resolution]] 3.50&Aring;' scene=''>

<table><tr><td colspan='2'>[[4fsj]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/Fhv Fhv] and [http://en.wikipedia.org/wiki/Spodoptera_frugiperda Spodoptera frugiperda]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2q26 2q26]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FSJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FSJ FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr>

<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nodavirus_endopeptidase Nodavirus endopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.44 3.4.23.44] </span></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fsj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fsj OCA], [http://pdbe.org/4fsj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4fsj RCSB], [http://www.ebi.ac.uk/pdbsum/4fsj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4fsj ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/CAPSD_FHV CAPSD_FHV]] Capsid protein alpha self-assembles to form an icosahedral procapsid with a T=3 symmetry, about 30 nm in diameter, and consisting of 60 capsid proteins trimers. In addition, 240 calcium ions are incorporated per capsid during assembly. The capsid encapsulates the two genomic RNAs. Capsid maturation occurs via autoproteolytic cleavage of capsid protein alpha generating capsid protein beta and the membrane-active peptide gamma. Peptide gamma: membrane-permeabilizing peptide produced by virus maturation, thereby creating the infectious virion. After endocytosis into the host cell, peptide gamma is probably exposed in endosomes, where it permeabilizes the endosomal membrane, facilitating translocation of viral capsid or RNA into the cytoplasm (Probable).

*[[Virus coat protein|Virus coat protein]]

[[Category: Fhv]]

[[Category: Nodavirus endopeptidase]]

[[Category: Chen, Z]]

[[Category: Johnson, J E]]

[[Category: Reddy, V S]]

[[Category: Speir, J A]]

[[Category: Virus]]