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| | <StructureSection load='4fw9' size='340' side='right'caption='[[4fw9]], [[Resolution|resolution]] 2.00Å' scene=''> | | <StructureSection load='4fw9' size='340' side='right'caption='[[4fw9]], [[Resolution|resolution]] 2.00Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[4fw9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_baa-399 Atcc baa-399]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FW9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FW9 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[4fw9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Meiothermus_taiwanensis Meiothermus taiwanensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FW9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FW9 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> |
| - | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fw9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fw9 OCA], [https://pdbe.org/4fw9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fw9 RCSB], [https://www.ebi.ac.uk/pdbsum/4fw9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fw9 ProSAT]</span></td></tr> |
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4fwd|4fwd]], [[4fwg|4fwg]], [[4fwh|4fwh]]</td></tr>
| + | |
| - | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Endopeptidase_La Endopeptidase La], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.53 3.4.21.53] </span></td></tr>
| + | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fw9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fw9 OCA], [http://pdbe.org/4fw9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4fw9 RCSB], [http://www.ebi.ac.uk/pdbsum/4fw9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4fw9 ProSAT]</span></td></tr> | + | |
| | </table> | | </table> |
| | + | == Function == |
| | + | [https://www.uniprot.org/uniprot/C9DRU9_9DEIN C9DRU9_9DEIN] |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| | == Publication Abstract from PubMed == | | == Publication Abstract from PubMed == |
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| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Atcc baa-399]] | |
| - | [[Category: Endopeptidase La]] | |
| | [[Category: Large Structures]] | | [[Category: Large Structures]] |
| - | [[Category: Chang, C I]] | + | [[Category: Meiothermus taiwanensis]] |
| - | [[Category: Huang, K F]] | + | [[Category: Chang CI]] |
| - | [[Category: Ihara, K]] | + | [[Category: Huang KF]] |
| - | [[Category: Kuo, C I]] | + | [[Category: Ihara K]] |
| - | [[Category: Wakatsuki, S]] | + | [[Category: Kuo CI]] |
| - | [[Category: Hydrolase]]
| + | [[Category: Wakatsuki S]] |
| - | [[Category: Lon protease]]
| + | |
| Structural highlights
Function
C9DRU9_9DEIN
Publication Abstract from PubMed
The Lon proteases are a unique family of chambered proteases with a built-in AAA+ (ATPases associated with diverse cellular activities) module. Here, crystal structures of a unique member of the Lon family with no intrinsic ATPase activity in the proteolytically active form are reported both alone and in complexes with three covalent inhibitors: two peptidomimetics and one derived from a natural product. This work reveals the unique architectural features of an ATP-independent Lon that selectively degrades unfolded protein substrates. Importantly, these results provide mechanistic insights into the recognition of inhibitors and polypeptide substrates within the conserved proteolytic chamber, which may aid the development of specific Lon-protease inhibitors.
Structures of an ATP-independent Lon-like protease and its complexes with covalent inhibitors.,Liao JH, Ihara K, Kuo CI, Huang KF, Wakatsuki S, Wu SH, Chang CI Acta Crystallogr D Biol Crystallogr. 2013 Aug;69(Pt 8):1395-402. doi:, 10.1107/S0907444913008214. Epub 2013 Jul 13. PMID:23897463[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Liao JH, Ihara K, Kuo CI, Huang KF, Wakatsuki S, Wu SH, Chang CI. Structures of an ATP-independent Lon-like protease and its complexes with covalent inhibitors. Acta Crystallogr D Biol Crystallogr. 2013 Aug;69(Pt 8):1395-402. doi:, 10.1107/S0907444913008214. Epub 2013 Jul 13. PMID:23897463 doi:10.1107/S0907444913008214
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