4fzs
From Proteopedia
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==Structure of human SNX1 BAR domain== | ==Structure of human SNX1 BAR domain== | ||
| - | <StructureSection load='4fzs' size='340' side='right' caption='[[4fzs]], [[Resolution|resolution]] 2.80Å' scene=''> | + | <StructureSection load='4fzs' size='340' side='right'caption='[[4fzs]], [[Resolution|resolution]] 2.80Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4fzs]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4fzs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FZS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FZS FirstGlance]. <br> |
| - | </td></tr> | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fzs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fzs OCA], [https://pdbe.org/4fzs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fzs RCSB], [https://www.ebi.ac.uk/pdbsum/4fzs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fzs ProSAT]</span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/SNX1_HUMAN SNX1_HUMAN] May be involved in several stages of intracellular trafficking. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi. Component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2).<ref>PMID:12198132</ref> <ref>PMID:15498486</ref> <ref>PMID:17101778</ref> |
==See Also== | ==See Also== | ||
| - | *[[Sorting nexin|Sorting nexin]] | + | *[[Sorting nexin 3D structures|Sorting nexin 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: Bhatia | + | [[Category: Large Structures]] |
| - | [[Category: Cullen | + | [[Category: Bhatia VK]] |
| - | [[Category: Hurley | + | [[Category: Cullen PJ]] |
| - | [[Category: Kloer | + | [[Category: Hurley JH]] |
| - | [[Category: Sessions | + | [[Category: Kloer DP]] |
| - | [[Category: Stamou | + | [[Category: Sessions RB]] |
| - | [[Category: Traer | + | [[Category: Stamou D]] |
| - | [[Category: Weering | + | [[Category: Traer CJ]] |
| - | + | [[Category: Van Weering JRT]] | |
| - | + | ||
| - | + | ||
Revision as of 20:16, 19 October 2022
Structure of human SNX1 BAR domain
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Categories: Homo sapiens | Large Structures | Bhatia VK | Cullen PJ | Hurley JH | Kloer DP | Sessions RB | Stamou D | Traer CJ | Van Weering JRT
