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| | ==Crystal structure of Newcastle disease virus matrix protein== | | ==Crystal structure of Newcastle disease virus matrix protein== |
| - | <StructureSection load='4g1o' size='340' side='right' caption='[[4g1o]], [[Resolution|resolution]] 2.20Å' scene=''> | + | <StructureSection load='4g1o' size='340' side='right'caption='[[4g1o]], [[Resolution|resolution]] 2.20Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[4g1o]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ndv Ndv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G1O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4G1O FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[4g1o]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Newcastle_disease_virus_(STRAIN_AUSTRALIA-VICTORIA/32) Newcastle disease virus (STRAIN AUSTRALIA-VICTORIA/32)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G1O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4G1O FirstGlance]. <br> |
| - | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4g1g|4g1g]], [[4g1l|4g1l]]</td></tr> | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g1o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g1o OCA], [https://pdbe.org/4g1o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g1o RCSB], [https://www.ebi.ac.uk/pdbsum/4g1o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g1o ProSAT]</span></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">M ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11177 NDV])</td></tr>
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| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g1o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g1o OCA], [http://pdbe.org/4g1o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4g1o RCSB], [http://www.ebi.ac.uk/pdbsum/4g1o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4g1o ProSAT]</span></td></tr> | + | |
| | </table> | | </table> |
| | == Function == | | == Function == |
| - | [[http://www.uniprot.org/uniprot/MATRX_NDVA MATRX_NDVA]] The M protein has a crucial role in virus assembly and interacts with the RNP complex as well as with the viral membrane. | + | [https://www.uniprot.org/uniprot/MATRX_NDVA MATRX_NDVA] The M protein has a crucial role in virus assembly and interacts with the RNP complex as well as with the viral membrane. |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| | == Publication Abstract from PubMed == | | == Publication Abstract from PubMed == |
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| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Ndv]] | + | [[Category: Large Structures]] |
| - | [[Category: Meng, G]] | + | [[Category: Meng G]] |
| - | [[Category: Rossmann, M G]] | + | [[Category: Rossmann MG]] |
| - | [[Category: Beta-strand]]
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| - | [[Category: Membrane]]
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| - | [[Category: Viral protein]]
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| - | [[Category: Virus]]
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| - | [[Category: Virus assembly]]
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| Structural highlights
Function
MATRX_NDVA The M protein has a crucial role in virus assembly and interacts with the RNP complex as well as with the viral membrane.
Publication Abstract from PubMed
Many pleomorphic, lipid-enveloped viruses encode matrix proteins that direct their assembly and budding, but the mechanism of this process is unclear. We have combined X-ray crystallography and cryoelectron tomography to show that the matrix protein of Newcastle disease virus, a paramyxovirus and relative of measles virus, forms dimers that assemble into pseudotetrameric arrays that generate the membrane curvature necessary for virus budding. We show that the glycoproteins are anchored in the gaps between the matrix proteins and that the helical nucleocapsids are associated in register with the matrix arrays. About 90% of virions lack matrix arrays, suggesting that, in agreement with previous biological observations, the matrix protein needs to dissociate from the viral membrane during maturation, as is required for fusion and release of the nucleocapsid into the host's cytoplasm. Structure and sequence conservation imply that other paramyxovirus matrix proteins function similarly.
Structure and assembly of a paramyxovirus matrix protein.,Battisti AJ, Meng G, Winkler DC, McGinnes LW, Plevka P, Steven AC, Morrison TG, Rossmann MG Proc Natl Acad Sci U S A. 2012 Aug 13. PMID:22891297[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Battisti AJ, Meng G, Winkler DC, McGinnes LW, Plevka P, Steven AC, Morrison TG, Rossmann MG. Structure and assembly of a paramyxovirus matrix protein. Proc Natl Acad Sci U S A. 2012 Aug 13. PMID:22891297 doi:10.1073/pnas.1210275109
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