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4g33

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==Crystal Structure of a Phospholipid-Lipoxygenase Complex from Pseudomonas aeruginosa at 2.0 A (C2221)==
==Crystal Structure of a Phospholipid-Lipoxygenase Complex from Pseudomonas aeruginosa at 2.0 A (C2221)==
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<StructureSection load='4g33' size='340' side='right' caption='[[4g33]], [[Resolution|resolution]] 2.03&Aring;' scene=''>
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<StructureSection load='4g33' size='340' side='right'caption='[[4g33]], [[Resolution|resolution]] 2.03&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4g33]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_aeruginosus"_(schroeter_1872)_trevisan_1885 "bacillus aeruginosus" (schroeter 1872) trevisan 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G33 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4G33 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4g33]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G33 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4G33 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZPE:(2R)-3-{[(S)-(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-2-(TETRADEC-5-ENOYLOXY)PROPYL+(11Z)-OCTADEC-11-ENOATE'>ZPE</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZPE:(2R)-3-{[(S)-(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-2-(TETRADEC-5-ENOYLOXY)PROPYL+(11Z)-OCTADEC-11-ENOATE'>ZPE</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4g32|4g32]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g33 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g33 OCA], [https://pdbe.org/4g33 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g33 RCSB], [https://www.ebi.ac.uk/pdbsum/4g33 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g33 ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">lox ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 "Bacillus aeruginosus" (Schroeter 1872) Trevisan 1885])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g33 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g33 OCA], [http://pdbe.org/4g33 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4g33 RCSB], [http://www.ebi.ac.uk/pdbsum/4g33 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4g33 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/LOX_PSEAI LOX_PSEAI]] In presence of oxygen, converts oleic acid into (S)-(E)-10-hydroperoxy-8-octadecenoic acid (HPOD), which spontaneously decomposes to the corresponding (E)-10-hydroxy-8-octadecenoic acid (HOD). In vivo, the reaction leads to the dihydroxy derivative (E)-7,10-dihydroxy-8-octadecenoic acid (DHOD), so that the three hydroxy-fatty acids can be isolated from the culture medium. Also active on linoleic acid and linolenic acid. Almost not active on arachidonic acid.
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[https://www.uniprot.org/uniprot/LOX_PSEAI LOX_PSEAI] In presence of oxygen, converts oleic acid into (S)-(E)-10-hydroperoxy-8-octadecenoic acid (HPOD), which spontaneously decomposes to the corresponding (E)-10-hydroxy-8-octadecenoic acid (HOD). In vivo, the reaction leads to the dihydroxy derivative (E)-7,10-dihydroxy-8-octadecenoic acid (DHOD), so that the three hydroxy-fatty acids can be isolated from the culture medium. Also active on linoleic acid and linolenic acid. Almost not active on arachidonic acid.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Carpena, X]]
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[[Category: Large Structures]]
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[[Category: Fita, I]]
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[[Category: Pseudomonas aeruginosa]]
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[[Category: Garcia-Fernandez, Q]]
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[[Category: Carpena X]]
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[[Category: Garreta, A]]
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[[Category: Fita I]]
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[[Category: Val-Moraes, S P]]
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[[Category: Garcia-Fernandez Q]]
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[[Category: Non-heme iron enzyme]]
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[[Category: Garreta A]]
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[[Category: Oxidoreductase]]
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[[Category: Val-Moraes SP]]
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[[Category: Protein-phospholipid complex]]
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Revision as of 20:22, 19 October 2022

Crystal Structure of a Phospholipid-Lipoxygenase Complex from Pseudomonas aeruginosa at 2.0 A (C2221)

PDB ID 4g33

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