4g3i

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==Crystal structure of Dpo4 in complex with DNA duplex==
==Crystal structure of Dpo4 in complex with DNA duplex==
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<StructureSection load='4g3i' size='340' side='right' caption='[[4g3i]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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<StructureSection load='4g3i' size='340' side='right'caption='[[4g3i]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4g3i]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulso Sulso]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G3I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4G3I FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4g3i]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharolobus_solfataricus_P2 Saccharolobus solfataricus P2] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G3I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4G3I FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2agq|2agq]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g3i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g3i OCA], [https://pdbe.org/4g3i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g3i RCSB], [https://www.ebi.ac.uk/pdbsum/4g3i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g3i ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">dbh, dpo4, SSO2448 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=273057 SULSO])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-directed_DNA_polymerase DNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.7 2.7.7.7] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g3i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g3i OCA], [http://pdbe.org/4g3i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4g3i RCSB], [http://www.ebi.ac.uk/pdbsum/4g3i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4g3i ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/DPO4_SULSO DPO4_SULSO]] Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. It is involved in translesional synthesis.[HAMAP-Rule:MF_01113]
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[https://www.uniprot.org/uniprot/DPO4_SACS2 DPO4_SACS2] Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. It is involved in translesional synthesis.
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==See Also==
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*[[DNA polymerase|DNA polymerase]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: DNA-directed DNA polymerase]]
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[[Category: Large Structures]]
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[[Category: Sulso]]
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[[Category: Saccharolobus solfataricus P2]]
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[[Category: Gan, J H]]
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[[Category: Synthetic construct]]
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[[Category: Huang, Z]]
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[[Category: Gan JH]]
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[[Category: Yan, Y Y]]
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[[Category: Huang Z]]
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[[Category: Dna synthesis]]
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[[Category: Yan YY]]
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[[Category: Transferase-dna complex]]
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Revision as of 20:22, 19 October 2022

Crystal structure of Dpo4 in complex with DNA duplex

PDB ID 4g3i

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