7ukz
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==CDK11 in complex with small molecule inhibitor OTS964== | |
| - | + | <StructureSection load='7ukz' size='340' side='right'caption='[[7ukz]], [[Resolution|resolution]] 2.60Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[7ukz]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7UKZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7UKZ FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NK3:OTS964'>NK3</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ukz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ukz OCA], [https://pdbe.org/7ukz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ukz RCSB], [https://www.ebi.ac.uk/pdbsum/7ukz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ukz ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: Kelso | + | == Function == |
| + | [https://www.uniprot.org/uniprot/CD11B_HUMAN CD11B_HUMAN] Plays multiple roles in cell cycle progression, cytokinesis and apoptosis. Involved in pre-mRNA splicing in a kinase activity-dependent manner. Isoform 7 may act as a negative regulator of normal cell cycle progression.<ref>PMID:12501247</ref> <ref>PMID:12624090</ref> <ref>PMID:18216018</ref> <ref>PMID:2217177</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Kelso S]] | ||
| + | [[Category: Sicheri F]] | ||
Revision as of 06:04, 26 October 2022
CDK11 in complex with small molecule inhibitor OTS964
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