8e4q
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | The | + | ==The closed C0-state flycatcher TRPM8 structure in complex with PI(4,5)P2== |
| + | <StructureSection load='8e4q' size='340' side='right'caption='[[8e4q]], [[Resolution|resolution]] 3.51Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[8e4q]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Ficedula_albicollis Ficedula albicollis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8E4Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8E4Q FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PIO:[(2R)-2-OCTANOYLOXY-3-[OXIDANYL-[(1R,2R,3S,4R,5R,6S)-2,3,6-TRIS(OXIDANYL)-4,5-DIPHOSPHONOOXY-CYCLOHEXYL]OXY-PHOSPHORYL]OXY-PROPYL]+OCTANOATE'>PIO</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8e4q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8e4q OCA], [https://pdbe.org/8e4q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8e4q RCSB], [https://www.ebi.ac.uk/pdbsum/8e4q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8e4q ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/U3JD03_FICAL U3JD03_FICAL] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The transient receptor potential melastatin 8 (TRPM8) channel is the primary molecular transducer responsible for the cool sensation elicited by menthol and cold in mammals. TRPM8 activation is controlled by cooling compounds together with the membrane lipid phosphatidylinositol 4,5-bisphosphate (PIP2). Our knowledge of cold sensation and the therapeutic potential of TRPM8 for neuroinflammatory diseases and pain will be enhanced by understanding the structural basis of cooling agonist- and PIP2-dependent TRPM8 activation. We present cryo-electron microscopy structures of mouse TRPM8 in closed, intermediate, and open states along the ligand- and PIP2-dependent gating pathway. Our results uncover two discrete agonist sites, state-dependent rearrangements in the gate positions, and a disordered-to-ordered transition of the gate-forming S6-elucidating the molecular basis of chemically induced cool sensation in mammals. | ||
| - | + | Activation mechanism of the mouse cold-sensing TRPM8 channel by cooling agonist and PIP2.,Yin Y, Zhang F, Feng S, Butay KJ, Borgnia MJ, Im W, Lee SY Science. 2022 Oct 14;378(6616):eadd1268. doi: 10.1126/science.add1268. Epub 2022 , Oct 14. PMID:36227998<ref>PMID:36227998</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 8e4q" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Ficedula albicollis]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Borgnia MJ]] | ||
| + | [[Category: Butay KJ]] | ||
| + | [[Category: Feng S]] | ||
| + | [[Category: Im W]] | ||
| + | [[Category: Lee S-Y]] | ||
| + | [[Category: Yin Y]] | ||
| + | [[Category: Zhang F]] | ||
Revision as of 06:11, 26 October 2022
The closed C0-state flycatcher TRPM8 structure in complex with PI(4,5)P2
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Categories: Ficedula albicollis | Large Structures | Borgnia MJ | Butay KJ | Feng S | Im W | Lee S-Y | Yin Y | Zhang F
