1is7

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[[Image:1is7.gif|left|200px]]
[[Image:1is7.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1is7 |SIZE=350|CAPTION= <scene name='initialview01'>1is7</scene>, resolution 2.8&Aring;
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The line below this paragraph, containing "STRUCTURE_1is7", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=PHE:PHENYLALANINE'>PHE</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/GTP_cyclohydrolase_I GTP cyclohydrolase I], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.4.16 3.5.4.16] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1is7| PDB=1is7 | SCENE= }}
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|RELATEDENTRY=[[1is8|1IS8]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1is7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1is7 OCA], [http://www.ebi.ac.uk/pdbsum/1is7 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1is7 RCSB]</span>
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'''Crystal structure of rat GTPCHI/GFRP stimulatory complex'''
'''Crystal structure of rat GTPCHI/GFRP stimulatory complex'''
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[[Category: Maita, N.]]
[[Category: Maita, N.]]
[[Category: Okada, K.]]
[[Category: Okada, K.]]
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[[Category: enzyme-regulatory protein complex]]
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[[Category: Enzyme-regulatory protein complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:21:09 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:23:55 2008''
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Revision as of 17:21, 2 May 2008

Image:1is7.gif

Template:STRUCTURE 1is7

Crystal structure of rat GTPCHI/GFRP stimulatory complex


Overview

In the presence of phenylalanine, GTP cyclohydrolase I feedback regulatory protein (GFRP) forms a stimulatory 360-kDa complex with GTP cyclohydrolase I (GTPCHI), which is the rate-limiting enzyme in the biosynthesis of tetrahydrobiopterin. The crystal structure of the stimulatory complex reveals that the GTPCHI decamer is sandwiched by two GFRP homopentamers. Each GFRP pentamer forms a symmetrical five-membered ring similar to beta-propeller. Five phenylalanine molecules are buried inside each interface between GFRP and GTPCHI, thus enhancing the binding of these proteins. The complex structure suggests that phenylalanine-induced GTPCHI x GFRP complex formation enhances GTPCHI activity by locking the enzyme in the active state.

About this Structure

1IS7 is a Protein complex structure of sequences from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Crystal structure of the stimulatory complex of GTP cyclohydrolase I and its feedback regulatory protein GFRP., Maita N, Okada K, Hatakeyama K, Hakoshima T, Proc Natl Acad Sci U S A. 2002 Feb 5;99(3):1212-7. Epub 2002 Jan 29. PMID:11818540 Page seeded by OCA on Fri May 2 20:21:09 2008

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