4g88

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==Crystal structure of OmpA peptidoglycan-binding domain from Acinetobacter baumannii==
==Crystal structure of OmpA peptidoglycan-binding domain from Acinetobacter baumannii==
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<StructureSection load='4g88' size='340' side='right' caption='[[4g88]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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<StructureSection load='4g88' size='340' side='right'caption='[[4g88]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4g88]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Aciba Aciba]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G88 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4G88 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4g88]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Acinetobacter_baumannii Acinetobacter baumannii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G88 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4G88 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=API:2,6-DIAMINOPIMELIC+ACID'>API</scene>, <scene name='pdbligand=SRT:S,R+MESO-TARTARIC+ACID'>SRT</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=API:2,6-DIAMINOPIMELIC+ACID'>API</scene>, <scene name='pdbligand=SRT:S,R+MESO-TARTARIC+ACID'>SRT</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4g4v|4g4v]], [[4g4w|4g4w]], [[4g4x|4g4x]], [[4g4y|4g4y]], [[4g4z|4g4z]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g88 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g88 OCA], [https://pdbe.org/4g88 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g88 RCSB], [https://www.ebi.ac.uk/pdbsum/4g88 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g88 ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">omp38, ompA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=470 ACIBA])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g88 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g88 OCA], [http://pdbe.org/4g88 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4g88 RCSB], [http://www.ebi.ac.uk/pdbsum/4g88 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4g88 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/OMP38_ACIBA OMP38_ACIBA]] Porin. Induces apoptosis in human laryngeal epithelial HEp-2 cells through caspases-dependent and AIF-dependent pathways. Purified Omp38 enters the cells and localizes to the mitochondria, which leads to a release of proapoptotic molecules such as cytochrome c and AIF (apoptosis-inducing factor).<ref>PMID:16008580</ref> <ref>PMID:9928952</ref>
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[https://www.uniprot.org/uniprot/OMP38_ACIB2 OMP38_ACIB2] Functions as a porin (PubMed:9928952). Induces apoptosis in human cell lines through caspase-dependent and AIF-dependent pathways. Purified Omp38 enters host cell and localizes to the mitochondria, which presumably leads to a release of proapoptotic molecules such as cytochrome c and AIF (apoptosis-inducing factor) (PubMed:16008580). Binds peptidoglycan, contributes to cell wall maintenance (Probable).<ref>PMID:16008580</ref> <ref>PMID:9928952</ref> <ref>PMID:16008580</ref> <ref>PMID:21965596</ref>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Aciba]]
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[[Category: Acinetobacter baumannii]]
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[[Category: Kim, H Y]]
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[[Category: Large Structures]]
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[[Category: Lee, W C]]
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[[Category: Kim HY]]
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[[Category: Park, J S]]
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[[Category: Lee WC]]
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[[Category: Song, J H]]
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[[Category: Park JS]]
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[[Category: Ompa-like domain]]
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[[Category: Song JH]]
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[[Category: Peptide binding protein]]
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Revision as of 06:41, 26 October 2022

Crystal structure of OmpA peptidoglycan-binding domain from Acinetobacter baumannii

PDB ID 4g88

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