4gah

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==Human acyl-CoA thioesterases 4 in complex with undecan-2-one-CoA inhibitor==
==Human acyl-CoA thioesterases 4 in complex with undecan-2-one-CoA inhibitor==
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<StructureSection load='4gah' size='340' side='right' caption='[[4gah]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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<StructureSection load='4gah' size='340' side='right'caption='[[4gah]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4gah]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GAH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GAH FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4gah]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GAH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GAH FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0ET:[[(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-4-OXIDANYL-3-PHOSPHONOOXY-OXOLAN-2-YL]METHOXY-OXIDANYL-PHOSPHORYL]+[(3R)-2,2-DIMETHYL-3-OXIDANYL-4-OXIDANYLIDENE-4-[[3-OXIDANYLIDENE-3-[2-[(2R)-2-OXIDANYLUNDECYL]SULFANYLETHYLAMINO]PROPYL]AMINO]BUTYL]+HYDROGEN+PHOSPHATE'>0ET</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0ET:[[(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-4-OXIDANYL-3-PHOSPHONOOXY-OXOLAN-2-YL]METHOXY-OXIDANYL-PHOSPHORYL]+[(3R)-2,2-DIMETHYL-3-OXIDANYL-4-OXIDANYLIDENE-4-[[3-OXIDANYLIDENE-3-[2-[(2R)-2-OXIDANYLUNDECYL]SULFANYLETHYLAMINO]PROPYL]AMINO]BUTYL]+HYDROGEN+PHOSPHATE'>0ET</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CTMP, THEM4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gah OCA], [https://pdbe.org/4gah PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gah RCSB], [https://www.ebi.ac.uk/pdbsum/4gah PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gah ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acyl-CoA_hydrolase Acyl-CoA hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.2.20 3.1.2.20] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gah OCA], [http://pdbe.org/4gah PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4gah RCSB], [http://www.ebi.ac.uk/pdbsum/4gah PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4gah ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/THEM4_HUMAN THEM4_HUMAN]] Has acyl-CoA thioesterase activity towards medium and long-chain (C14 to C18) fatty acyl-CoA substrates, and probably plays an role in mitochondrial fatty acid metabolism. Plays a role in the apoptotic process, possibly via its regulation of AKT1 activity. According to PubMed:11598301, inhibits AKT1 phosphorylation and activity. According to PubMed:17615157, enhances AKT1 activity by favoring its phosphorylation and translocation to plasma membrane.<ref>PMID:11598301</ref> <ref>PMID:17615157</ref> <ref>PMID:19453107</ref> <ref>PMID:19168129</ref> <ref>PMID:19421406</ref> <ref>PMID:22871024</ref>
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[https://www.uniprot.org/uniprot/THEM4_HUMAN THEM4_HUMAN] Has acyl-CoA thioesterase activity towards medium and long-chain (C14 to C18) fatty acyl-CoA substrates, and probably plays an role in mitochondrial fatty acid metabolism. Plays a role in the apoptotic process, possibly via its regulation of AKT1 activity. According to PubMed:11598301, inhibits AKT1 phosphorylation and activity. According to PubMed:17615157, enhances AKT1 activity by favoring its phosphorylation and translocation to plasma membrane.<ref>PMID:11598301</ref> <ref>PMID:17615157</ref> <ref>PMID:19453107</ref> <ref>PMID:19168129</ref> <ref>PMID:19421406</ref> <ref>PMID:22871024</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Acyl-CoA hydrolase]]
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[[Category: Homo sapiens]]
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[[Category: Human]]
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[[Category: Large Structures]]
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[[Category: Herzberg, O]]
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[[Category: Herzberg O]]
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[[Category: Lim, K]]
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[[Category: Lim K]]
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[[Category: Pathak, M C]]
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[[Category: Pathak MC]]
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[[Category: Acyl coa hydrolase]]
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[[Category: Acyl-coa]]
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[[Category: Akt c-terminal modulating protein]]
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[[Category: Hotdog fold]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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Revision as of 06:45, 26 October 2022

Human acyl-CoA thioesterases 4 in complex with undecan-2-one-CoA inhibitor

PDB ID 4gah

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