4ge4

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
==Kynurenine Aminotransferase II Inhibitors==
==Kynurenine Aminotransferase II Inhibitors==
-
<StructureSection load='4ge4' size='340' side='right' caption='[[4ge4]], [[Resolution|resolution]] 2.41&Aring;' scene=''>
+
<StructureSection load='4ge4' size='340' side='right'caption='[[4ge4]], [[Resolution|resolution]] 2.41&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[4ge4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GE4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GE4 FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[4ge4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GE4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GE4 FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0KE:(5-HYDROXY-4-{[(1-HYDROXY-7-METHOXY-2-OXO-1,2-DIHYDROQUINOLIN-3-YL)AMINO]METHYL}-6-METHYLPYRIDIN-3-YL)METHYL+DIHYDROGEN+PHOSPHATE'>0KE</scene></td></tr>
+
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0KE:(5-HYDROXY-4-{[(1-HYDROXY-7-METHOXY-2-OXO-1,2-DIHYDROQUINOLIN-3-YL)AMINO]METHYL}-6-METHYLPYRIDIN-3-YL)METHYL+DIHYDROGEN+PHOSPHATE'>0KE</scene></td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4gdy|4gdy]], [[4ge9|4ge9]], [[4ge7|4ge7]], [[4geb|4geb]], [[3ue8|3ue8]]</td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ge4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ge4 OCA], [https://pdbe.org/4ge4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ge4 RCSB], [https://www.ebi.ac.uk/pdbsum/4ge4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ge4 ProSAT]</span></td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">AADAT, KAT2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ge4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ge4 OCA], [http://pdbe.org/4ge4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ge4 RCSB], [http://www.ebi.ac.uk/pdbsum/4ge4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ge4 ProSAT]</span></td></tr>
+
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/AADAT_HUMAN AADAT_HUMAN]] Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino-group acceptors, with a preference for 2-oxoglutarate, 2-oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro).<ref>PMID:18620547</ref>
+
[https://www.uniprot.org/uniprot/AADAT_HUMAN AADAT_HUMAN] Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino-group acceptors, with a preference for 2-oxoglutarate, 2-oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro).<ref>PMID:18620547</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 24: Line 22:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Human]]
+
[[Category: Homo sapiens]]
-
[[Category: Pandit, J]]
+
[[Category: Large Structures]]
-
[[Category: Aminotransferase]]
+
[[Category: Pandit J]]
-
[[Category: Irreversible inhibitor]]
+
-
[[Category: Transferase-transferase inhibitor complex]]
+

Revision as of 06:50, 26 October 2022

Kynurenine Aminotransferase II Inhibitors

PDB ID 4ge4

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4ge4"
Personal tools