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4gos

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Current revision (07:08, 26 October 2022) (edit) (undo)
 
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<StructureSection load='4gos' size='340' side='right'caption='[[4gos]], [[Resolution|resolution]] 1.59&Aring;' scene=''>
<StructureSection load='4gos' size='340' side='right'caption='[[4gos]], [[Resolution|resolution]] 1.59&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4gos]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GOS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GOS FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4gos]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GOS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GOS FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">B7-H4, B7H4, B7S1, B7x, UNQ659/PRO1291, VTCN1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gos OCA], [https://pdbe.org/4gos PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gos RCSB], [https://www.ebi.ac.uk/pdbsum/4gos PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gos ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gos OCA], [http://pdbe.org/4gos PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4gos RCSB], [http://www.ebi.ac.uk/pdbsum/4gos PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4gos ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/VTCN1_HUMAN VTCN1_HUMAN]] Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation.<ref>PMID:15878339</ref> <ref>PMID:16606666</ref> <ref>PMID:17875732</ref> <ref>PMID:17509674</ref> [UniProtKB:Q7TSP5]
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[https://www.uniprot.org/uniprot/VTCN1_HUMAN VTCN1_HUMAN] Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation.<ref>PMID:15878339</ref> <ref>PMID:16606666</ref> <ref>PMID:17875732</ref> <ref>PMID:17509674</ref> [UniProtKB:Q7TSP5]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Almo, S C]]
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[[Category: Almo SC]]
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[[Category: Bhosle, R]]
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[[Category: Bhosle R]]
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[[Category: IFN, Atoms-to-Animals:.The Immune Function Network]]
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[[Category: Nathenson SG]]
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[[Category: Structural genomic]]
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[[Category: Ramagopal U]]
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[[Category: Nathenson, S G]]
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[[Category: Toro R]]
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[[Category: Ramagopal, U]]
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[[Category: Vigdorovich V]]
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[[Category: Toro, R]]
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[[Category: Vigdorovich, V]]
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[[Category: Adaptive immunity]]
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[[Category: Atoms-to-animals: the immune function network]]
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[[Category: Cell surface]]
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[[Category: Disulfide bond]]
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[[Category: Glycoprotein]]
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[[Category: Ifn]]
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[[Category: Immune system]]
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[[Category: Immunity]]
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[[Category: Immunoglobulin domain]]
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[[Category: Immunoglobulin variable-like domain]]
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[[Category: Nysgrc]]
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[[Category: PSI, Protein structure initiative]]
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[[Category: Psi-biology]]
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Current revision

Crystal structure of human B7-H4 IgV-like domain

PDB ID 4gos

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OCA

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