4gu0

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==Crystal structure of LSD2 with H3==
==Crystal structure of LSD2 with H3==
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<StructureSection load='4gu0' size='340' side='right' caption='[[4gu0]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
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<StructureSection load='4gu0' size='340' side='right'caption='[[4gu0]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4gu0]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GU0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GU0 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4gu0]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GU0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GU0 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">LSD2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gu0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gu0 OCA], [https://pdbe.org/4gu0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gu0 RCSB], [https://www.ebi.ac.uk/pdbsum/4gu0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gu0 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gu0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gu0 OCA], [http://pdbe.org/4gu0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4gu0 RCSB], [http://www.ebi.ac.uk/pdbsum/4gu0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4gu0 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/KDM1B_HUMAN KDM1B_HUMAN]] Histone demethylase that demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Required for de novo DNA methylation of a subset of imprinted genes during oogenesis. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3. Has no effect on tri-methylated 'Lys-4', mono-, di- or tri-methylated 'Lys-9', mono-, di- or tri-methylated 'Lys-27', mono-, di- or tri-methylated 'Lys-36' of histone H3, or on mono-, di- or tri-methylated 'Lys-20' of histone H4 (By similarity).
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[https://www.uniprot.org/uniprot/H33_HUMAN H33_HUMAN]
==See Also==
==See Also==
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*[[Lysine-specific histone demethylase|Lysine-specific histone demethylase]]
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*[[Lysine-specific histone demethylase 3D structures|Lysine-specific histone demethylase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Chen, F]]
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[[Category: Large Structures]]
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[[Category: Dong, Z]]
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[[Category: Chen F]]
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[[Category: Fang, J]]
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[[Category: Dong Z]]
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[[Category: Gong, W]]
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[[Category: Fang J]]
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[[Category: Xu, Y]]
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[[Category: Gong W]]
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[[Category: Yang, H]]
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[[Category: Xu Y]]
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[[Category: Zhu, T]]
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[[Category: Yang H]]
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[[Category: Histone demethylase]]
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[[Category: Zhu T]]
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[[Category: Oxidoreductase]]
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Revision as of 07:17, 26 October 2022

Crystal structure of LSD2 with H3

PDB ID 4gu0

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