4gvj
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
==Tyk2 (JH1) in complex with adenosine di-phosphate== | ==Tyk2 (JH1) in complex with adenosine di-phosphate== | ||
| - | <StructureSection load='4gvj' size='340' side='right' caption='[[4gvj]], [[Resolution|resolution]] 2.03Å' scene=''> | + | <StructureSection load='4gvj' size='340' side='right'caption='[[4gvj]], [[Resolution|resolution]] 2.03Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4gvj]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4gvj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GVJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GVJ FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gvj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gvj OCA], [https://pdbe.org/4gvj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gvj RCSB], [https://www.ebi.ac.uk/pdbsum/4gvj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gvj ProSAT]</span></td></tr> | |
| - | + | ||
| - | + | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Disease == | == Disease == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/TYK2_HUMAN TYK2_HUMAN] Mendelian susceptibility to mycobacterial diseases;Autosomal recessive hyper IgE syndrome. Defects in TYK2 are the cause of protein-tyrosine kinase 2 deficiency (TYK2 deficiency) [MIM:[https://omim.org/entry/611521 611521]; also known as autosomal recessive hyper-IgE syndrome (HIES) with atypical mycobacteriosis. TYK2 deficiency consists of a primary immunodeficiency characterized by recurrent skin abscesses, pneumonia, and highly elevated serum IgE. |
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/TYK2_HUMAN TYK2_HUMAN] Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.<ref>PMID:7526154</ref> |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 25: | Line 22: | ||
==See Also== | ==See Also== | ||
| - | *[[Tyrosine kinase|Tyrosine kinase]] | + | *[[Tyrosine kinase 3D structures|Tyrosine kinase 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Abbema | + | [[Category: Abbema AV]] |
| - | [[Category: Bao | + | [[Category: Bao L]] |
| - | [[Category: Barrett | + | [[Category: Barrett K]] |
| - | [[Category: Beresini | + | [[Category: Beresini M]] |
| - | [[Category: Berezhkovskiy | + | [[Category: Berezhkovskiy L]] |
| - | [[Category: Blair | + | [[Category: Blair W]] |
| - | [[Category: Chang | + | [[Category: Chang C]] |
| - | [[Category: Driscoll | + | [[Category: Driscoll J]] |
| - | [[Category: Eigenbrot | + | [[Category: Eigenbrot C]] |
| - | [[Category: Ghilardi | + | [[Category: Ghilardi N]] |
| - | [[Category: Gibbons | + | [[Category: Gibbons P]] |
| - | [[Category: Halladay | + | [[Category: Halladay J]] |
| - | [[Category: Johnson | + | [[Category: Johnson A]] |
| - | [[Category: Kohli | + | [[Category: Kohli PB]] |
| - | [[Category: Lai | + | [[Category: Lai Y]] |
| - | [[Category: Liang | + | [[Category: Liang J]] |
| - | [[Category: Liimatta | + | [[Category: Liimatta M]] |
| - | [[Category: Magnuson | + | [[Category: Magnuson S]] |
| - | [[Category: Mantik | + | [[Category: Mantik P]] |
| - | [[Category: Menghrajani | + | [[Category: Menghrajani K]] |
| - | [[Category: Murray | + | [[Category: Murray J]] |
| - | [[Category: Sambrone | + | [[Category: Sambrone A]] |
| - | [[Category: Shao | + | [[Category: Shao Y]] |
| - | [[Category: Shia | + | [[Category: Shia S]] |
| - | [[Category: Shin | + | [[Category: Shin Y]] |
| - | [[Category: Smith | + | [[Category: Smith J]] |
| - | [[Category: Sohn | + | [[Category: Sohn S]] |
| - | [[Category: Stanley | + | [[Category: Stanley M]] |
| - | [[Category: Tsui | + | [[Category: Tsui V]] |
| - | [[Category: Ultsch | + | [[Category: Ultsch M]] |
| - | [[Category: Wu | + | [[Category: Wu L]] |
| - | [[Category: Zhang | + | [[Category: Zhang B]] |
| - | + | ||
| - | + | ||
Revision as of 07:20, 26 October 2022
Tyk2 (JH1) in complex with adenosine di-phosphate
| |||||||||||
Categories: Homo sapiens | Large Structures | Abbema AV | Bao L | Barrett K | Beresini M | Berezhkovskiy L | Blair W | Chang C | Driscoll J | Eigenbrot C | Ghilardi N | Gibbons P | Halladay J | Johnson A | Kohli PB | Lai Y | Liang J | Liimatta M | Magnuson S | Mantik P | Menghrajani K | Murray J | Sambrone A | Shao Y | Shia S | Shin Y | Smith J | Sohn S | Stanley M | Tsui V | Ultsch M | Wu L | Zhang B
