1iu9

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[[Image:1iu9.jpg|left|200px]]
[[Image:1iu9.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1iu9 |SIZE=350|CAPTION= <scene name='initialview01'>1iu9</scene>, resolution 2.04&Aring;
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The line below this paragraph, containing "STRUCTURE_1iu9", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Aspartate_racemase Aspartate racemase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.1.1.13 5.1.1.13] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= pPH0670E ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=53953 Pyrococcus horikoshii])
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|DOMAIN=
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{{STRUCTURE_1iu9| PDB=1iu9 | SCENE= }}
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|RELATEDENTRY=[[1jfl|1jfl]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1iu9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1iu9 OCA], [http://www.ebi.ac.uk/pdbsum/1iu9 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1iu9 RCSB]</span>
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}}
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'''Crystal structure of the C-terminal domain of aspartate racemase from Pyrococcus horikoshii OT3'''
'''Crystal structure of the C-terminal domain of aspartate racemase from Pyrococcus horikoshii OT3'''
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[[Category: Miki, K.]]
[[Category: Miki, K.]]
[[Category: Yohda, M.]]
[[Category: Yohda, M.]]
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[[Category: aspartate racemase]]
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[[Category: Aspartate racemase]]
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[[Category: c-terminal domain]]
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[[Category: C-terminal domain]]
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[[Category: crystal structure]]
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[[Category: Crystal structure]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:25:26 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:24:44 2008''
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Revision as of 17:25, 2 May 2008

Image:1iu9.jpg

Template:STRUCTURE 1iu9

Crystal structure of the C-terminal domain of aspartate racemase from Pyrococcus horikoshii OT3


Overview

The X-ray crystal structure has revealed two similar alpha/beta domains of aspartate racemase (AspR) from Pyrococcus horikoshii OT3, and identified a pseudo mirror-symmetric distribution of the residues around its active site [Liu et al. (2002) J. Mol. Biol. 319, 479-489]. Structural homology and functional similarity between the two domains suggested that this enzyme evolved from an ancestral domain by gene duplication and gene fusion. We have expressed solely the C-terminal domain of this AspR and determined its three-dimensional structure by X-ray crystallography. The high structural stability of this domain supports the existence of the ancestral domain. In comparison with other amino acid racemases (AARs), we suggest that gene duplication and gene fusion are conventional ways in the evolution of pyridoxal 5'-phosphate-independent AARs.

About this Structure

1IU9 is a Single protein structure of sequence from Pyrococcus horikoshii. Full crystallographic information is available from OCA.

Reference

Structural insight into gene duplication, gene fusion and domain swapping in the evolution of PLP-independent amino acid racemases., Liu L, Iwata K, Yohda M, Miki K, FEBS Lett. 2002 Sep 25;528(1-3):114-8. PMID:12297289 Page seeded by OCA on Fri May 2 20:25:26 2008

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