2wey

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<StructureSection load='2wey' size='340' side='right'caption='[[2wey]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
<StructureSection load='2wey' size='340' side='right'caption='[[2wey]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2wey]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WEY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WEY FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2wey]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WEY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WEY FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EV1:1-(3,4-DIMETHOXYBENZYL)-6,7-DIMETHOXYISOQUINOLINE'>EV1</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EV1:1-(3,4-DIMETHOXYBENZYL)-6,7-DIMETHOXYISOQUINOLINE'>EV1</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1lrb|1lrb]]</div></td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wey FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wey OCA], [https://pdbe.org/2wey PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wey RCSB], [https://www.ebi.ac.uk/pdbsum/2wey PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wey ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wey FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wey OCA], [https://pdbe.org/2wey PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wey RCSB], [https://www.ebi.ac.uk/pdbsum/2wey PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wey ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Albrecht, C]]
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[[Category: Albrecht C]]
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[[Category: Andersen, O A]]
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[[Category: Andersen OA]]
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[[Category: Barker, J]]
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[[Category: Barker J]]
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[[Category: Felicetti, B]]
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[[Category: Felicetti B]]
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[[Category: Fryatt, T]]
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[[Category: Fryatt T]]
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[[Category: Hallett, D]]
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[[Category: Hallett D]]
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[[Category: Schonfeld, D L]]
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[[Category: Schonfeld DL]]
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[[Category: Toogood-Johnson, I]]
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[[Category: Toogood-Johnson I]]
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[[Category: Whittaker, M]]
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[[Category: Whittaker M]]
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[[Category: Allosteric enzyme]]
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[[Category: Alternative splicing]]
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[[Category: Camp]]
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[[Category: Camp-binding]]
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[[Category: Cgmp]]
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[[Category: Cgmp-binding]]
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[[Category: Cross-linking]]
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[[Category: Cytoplasm]]
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[[Category: Hydrolase]]
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[[Category: Magnesium]]
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[[Category: Metal-binding]]
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[[Category: Nucleotide-binding]]
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[[Category: Papaverine]]
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[[Category: Phosphodiesterase]]
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[[Category: Phosphoprotein]]
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[[Category: Polymorphism]]
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[[Category: Zinc]]
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Revision as of 07:27, 3 November 2022

Human PDE-papaverine complex obtained by ligand soaking of cross- linked protein crystals

PDB ID 2wey

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