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From Proteopedia
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== Disease == | == Disease == | ||
| - | + | [https://www.uniprot.org/uniprot/RPA2_HUMAN RPA2_HUMAN] Treacher-Collins syndrome. The disease is caused by variants affecting the gene represented in this entry. | |
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/RPA2_HUMAN RPA2_HUMAN] DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft.<ref>PMID:16809778</ref> | |
== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 07:36, 3 November 2022
Human RNA polymerase I
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Categories: Homo sapiens | Large Structures | Abascal-Palacios G | Bernecky C | Bleckmann A | Bruckmann A | Daiss JL | Engel C | Fuertges T | Heiss FB | Hoecherl M | Lamour V | Mars JC | Moss T | Panov K | Pilsl M | Ramsay E | Rudack T | Straub K | Tluckova K | Vannini A
