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4gz9

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==Mouse Neuropilin-1, extracellular domains 1-4 (a1a2b1b2)==
==Mouse Neuropilin-1, extracellular domains 1-4 (a1a2b1b2)==
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<StructureSection load='4gz9' size='340' side='right' caption='[[4gz9]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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<StructureSection load='4gz9' size='340' side='right'caption='[[4gz9]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4gz9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GZ9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GZ9 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4gz9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GZ9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GZ9 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4gz8|4gz8]], [[4gza|4gza]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gz9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gz9 OCA], [https://pdbe.org/4gz9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gz9 RCSB], [https://www.ebi.ac.uk/pdbsum/4gz9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gz9 ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Nrp1, Nrp ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gz9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gz9 OCA], [http://pdbe.org/4gz9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4gz9 RCSB], [http://www.ebi.ac.uk/pdbsum/4gz9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4gz9 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/NRP1_MOUSE NRP1_MOUSE]] Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, the PLGF-2 isoform of PGF, the VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis (By similarity).
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[https://www.uniprot.org/uniprot/NRP1_MOUSE NRP1_MOUSE] Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, the PLGF-2 isoform of PGF, the VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Lk3 transgenic mice]]
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[[Category: Large Structures]]
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[[Category: Janssen, B J.C]]
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[[Category: Mus musculus]]
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[[Category: Jones, E Y]]
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[[Category: Janssen BJC]]
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[[Category: Malinauskas, T]]
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[[Category: Jones EY]]
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[[Category: Siebold, C]]
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[[Category: Malinauskas T]]
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[[Category: Cell-cell signaling]]
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[[Category: Siebold C]]
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[[Category: Glycosilated]]
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[[Category: Multi-domain]]
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[[Category: Plexin]]
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[[Category: Semaphorin]]
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[[Category: Signaling protein]]
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[[Category: Transmembrane]]
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[[Category: Vegf]]
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Revision as of 07:49, 3 November 2022

Mouse Neuropilin-1, extracellular domains 1-4 (a1a2b1b2)

PDB ID 4gz9

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