1ivo

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[[Image:1ivo.gif|left|200px]]
[[Image:1ivo.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1ivo |SIZE=350|CAPTION= <scene name='initialview01'>1ivo</scene>, resolution 3.30&Aring;
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The line below this paragraph, containing "STRUCTURE_1ivo", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 and 2.7.10.2 2.7.10.1 and 2.7.10.2] </span>
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1ivo| PDB=1ivo | SCENE= }}
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|RELATEDENTRY=[[1jl9|1JL9]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ivo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ivo OCA], [http://www.ebi.ac.uk/pdbsum/1ivo PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ivo RCSB]</span>
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}}
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'''Crystal Structure of the Complex of Human Epidermal Growth Factor and Receptor Extracellular Domains.'''
'''Crystal Structure of the Complex of Human Epidermal Growth Factor and Receptor Extracellular Domains.'''
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[[Category: Yamanaka, M.]]
[[Category: Yamanaka, M.]]
[[Category: Yokoyama, S.]]
[[Category: Yokoyama, S.]]
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[[Category: glycoprotein]]
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[[Category: Glycoprotein]]
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[[Category: receptor]]
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[[Category: Receptor]]
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[[Category: repeat]]
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[[Category: Repeat]]
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[[Category: riken structural genomics/proteomics initiative]]
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[[Category: Riken structural genomics/proteomics initiative]]
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[[Category: rsgi]]
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[[Category: Rsgi]]
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[[Category: signal,]]
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[[Category: Signal]]
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[[Category: structural genomic]]
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[[Category: Structural genomic]]
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[[Category: transmembrane]]
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[[Category: Transmembrane]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:28:32 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:25:17 2008''
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Revision as of 17:28, 2 May 2008

Image:1ivo.gif

Template:STRUCTURE 1ivo

Crystal Structure of the Complex of Human Epidermal Growth Factor and Receptor Extracellular Domains.


Overview

Epidermal growth factor (EGF) regulates cell proliferation and differentiation by binding to the EGF receptor (EGFR) extracellular region, comprising domains I-IV, with the resultant dimerization of the receptor tyrosine kinase. In this study, the crystal structure of a 2:2 complex of human EGF and the EGFR extracellular region has been determined at 3.3 A resolution. EGFR domains I-III are arranged in a C shape, and EGF is docked between domains I and III. The 1:1 EGF*EGFR complex dimerizes through a direct receptor*receptor interaction, in which a protruding beta-hairpin arm of each domain II holds the body of the other. The unique "receptor-mediated dimerization" was verified by EGFR mutagenesis.

About this Structure

1IVO is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the complex of human epidermal growth factor and receptor extracellular domains., Ogiso H, Ishitani R, Nureki O, Fukai S, Yamanaka M, Kim JH, Saito K, Sakamoto A, Inoue M, Shirouzu M, Yokoyama S, Cell. 2002 Sep 20;110(6):775-87. PMID:12297050 Page seeded by OCA on Fri May 2 20:28:32 2008

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OCA

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