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| | ==Crystal structure of a putative iron superoxide dismutase from Trypanosoma cruzi bound to iron== | | ==Crystal structure of a putative iron superoxide dismutase from Trypanosoma cruzi bound to iron== |
| - | <StructureSection load='4h3e' size='340' side='right' caption='[[4h3e]], [[Resolution|resolution]] 2.25Å' scene=''> | + | <StructureSection load='4h3e' size='340' side='right'caption='[[4h3e]], [[Resolution|resolution]] 2.25Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[4h3e]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trycc Trycc]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H3E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4H3E FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[4h3e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_cruzi_strain_CL_Brener Trypanosoma cruzi strain CL Brener]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H3E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4H3E FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene></td></tr> |
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4f2n|4f2n]]</td></tr>
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4h3e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h3e OCA], [https://pdbe.org/4h3e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4h3e RCSB], [https://www.ebi.ac.uk/pdbsum/4h3e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4h3e ProSAT]</span></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Tc00.1047053509775.40 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=353153 TRYCC])</td></tr>
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| - | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Superoxide_dismutase Superoxide dismutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.15.1.1 1.15.1.1] </span></td></tr>
| + | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4h3e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h3e OCA], [http://pdbe.org/4h3e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4h3e RCSB], [http://www.ebi.ac.uk/pdbsum/4h3e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4h3e ProSAT]</span></td></tr> | + | |
| | </table> | | </table> |
| | == Function == | | == Function == |
| - | [[http://www.uniprot.org/uniprot/Q4DCQ3_TRYCC Q4DCQ3_TRYCC]] Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity).[RuleBase:RU000414] | + | [https://www.uniprot.org/uniprot/Q4DCQ3_TRYCC Q4DCQ3_TRYCC] Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity).[RuleBase:RU000414] |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| | == Publication Abstract from PubMed == | | == Publication Abstract from PubMed == |
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| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Superoxide dismutase]] | + | [[Category: Large Structures]] |
| - | [[Category: Trycc]] | + | [[Category: Trypanosoma cruzi strain CL Brener]] |
| - | [[Category: Structural genomic]]
| + | |
| - | [[Category: Antioxidant]]
| + | |
| - | [[Category: Chagas disease]]
| + | |
| - | [[Category: Hydrogen peroxide]]
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| - | [[Category: National institute of allergy and infectious disease]]
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| - | [[Category: Niaid]]
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| - | [[Category: Oxidoreductase]]
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| - | [[Category: Parasitic euglenoid trypanosome]]
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| - | [[Category: Radical oxygen species]]
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| - | [[Category: Radical scavenger]]
| + | |
| - | [[Category: Ssgcid]]
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| - | [[Category: Trypanosomiasis]]
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| Structural highlights
Function
Q4DCQ3_TRYCC Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity).[RuleBase:RU000414]
Publication Abstract from PubMed
Prior studies have highlighted the potential of superoxide dismutases as drug targets in eukaryotic pathogens. This report presents the structures of three iron-dependent superoxide dismutases (FeSODs) from Trypanosoma cruzi, Leishmania major and Babesia bovis. Comparison with existing structures from Plasmodium and other trypanosome isoforms shows a very conserved overall fold with subtle differences. In particular, structural data suggest that B. bovis FeSOD may display similar resistance to peroxynitrite-mediated inactivation via an intramolecular electron-transfer pathway as previously described in T. cruzi FeSOD isoform B, thus providing valuable information for structure-based drug design. Furthermore, lysine-acetylation results in T. cruzi indicate that acetylation occurs at a position close to that responsible for the regulation of acetylation-mediated activity in the human enzyme.
Iron superoxide dismutases in eukaryotic pathogens: new insights from Apicomplexa and Trypanosoma structures.,Phan IQ, Davies DR, Moretti NS, Shanmugam D, Cestari I, Anupama A, Fairman JW, Edwards TE, Stuart K, Schenkman S, Myler PJ Acta Crystallogr F Struct Biol Commun. 2015 May;71(Pt 5):615-21. doi:, 10.1107/S2053230X15004185. Epub 2015 May 7. PMID:25961325[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Phan IQ, Davies DR, Moretti NS, Shanmugam D, Cestari I, Anupama A, Fairman JW, Edwards TE, Stuart K, Schenkman S, Myler PJ. Iron superoxide dismutases in eukaryotic pathogens: new insights from Apicomplexa and Trypanosoma structures. Acta Crystallogr F Struct Biol Commun. 2015 May;71(Pt 5):615-21. doi:, 10.1107/S2053230X15004185. Epub 2015 May 7. PMID:25961325 doi:http://dx.doi.org/10.1107/S2053230X15004185
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