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4h4d

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==IspH in complex with (E)-4-amino-3-methylbut-2-enyl diphosphate==
==IspH in complex with (E)-4-amino-3-methylbut-2-enyl diphosphate==
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<StructureSection load='4h4d' size='340' side='right' caption='[[4h4d]], [[Resolution|resolution]] 1.35&Aring;' scene=''>
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<StructureSection load='4h4d' size='340' side='right'caption='[[4h4d]], [[Resolution|resolution]] 1.35&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4h4d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H4D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4H4D FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4h4d]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H4D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4H4D FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=10E:(2E)-4-AMINO-3-METHYLBUT-2-EN-1-YL+TRIHYDROGEN+DIPHOSPHATE'>10E</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=10E:(2E)-4-AMINO-3-METHYLBUT-2-EN-1-YL+TRIHYDROGEN+DIPHOSPHATE'>10E</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3ke8|3ke8]], [[3dnf|3dnf]], [[3f7t|3f7t]], [[4h4c|4h4c]], [[4h4e|4h4e]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4h4d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h4d OCA], [https://pdbe.org/4h4d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4h4d RCSB], [https://www.ebi.ac.uk/pdbsum/4h4d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4h4d ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">b0029, ispH, JW0027, lytB, yaaE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/4-hydroxy-3-methylbut-2-enyl_diphosphate_reductase 4-hydroxy-3-methylbut-2-enyl diphosphate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.17.1.2 1.17.1.2] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4h4d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h4d OCA], [http://pdbe.org/4h4d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4h4d RCSB], [http://www.ebi.ac.uk/pdbsum/4h4d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4h4d ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ISPH_ECOLI ISPH_ECOLI]] Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Is also involved in penicillin tolerance and control of the stringent response. Seems to directly or indirectly interact with RelA to maintain it in an inactive form during normal growth.<ref>PMID:19569147</ref> <ref>PMID:20080550</ref> <ref>PMID:22137895</ref>
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[https://www.uniprot.org/uniprot/ISPH_ECOLI ISPH_ECOLI] Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Is also involved in penicillin tolerance and control of the stringent response. Seems to directly or indirectly interact with RelA to maintain it in an inactive form during normal growth.<ref>PMID:19569147</ref> <ref>PMID:20080550</ref> <ref>PMID:22137895</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[4-hydroxy-3-methylbut-2-enyl diphosphate reductase|4-hydroxy-3-methylbut-2-enyl diphosphate reductase]]
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*[[4-hydroxy-3-methylbut-2-enyl diphosphate reductase 3D structures|4-hydroxy-3-methylbut-2-enyl diphosphate reductase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: 4-hydroxy-3-methylbut-2-enyl diphosphate reductase]]
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[[Category: Escherichia coli K-12]]
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[[Category: Ecoli]]
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[[Category: Large Structures]]
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[[Category: Bacher, A]]
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[[Category: Bacher A]]
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[[Category: Eisenreich, W]]
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[[Category: Eisenreich W]]
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[[Category: Groll, M]]
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[[Category: Groll M]]
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[[Category: Jauch, J]]
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[[Category: Jauch J]]
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[[Category: Span, I]]
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[[Category: Span I]]
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[[Category: Iron-sulfur protein]]
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[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
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[[Category: Reductase]]
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Revision as of 07:58, 3 November 2022

IspH in complex with (E)-4-amino-3-methylbut-2-enyl diphosphate

PDB ID 4h4d

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