1ivv
From Proteopedia
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[[Image:1ivv.jpg|left|200px]] | [[Image:1ivv.jpg|left|200px]] | ||
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'''Crystal structure of copper amine oxidase from Arthrobacter globiformis: Early intermediate in topaquinone biogenesis''' | '''Crystal structure of copper amine oxidase from Arthrobacter globiformis: Early intermediate in topaquinone biogenesis''' | ||
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==Reference== | ==Reference== | ||
X-ray snapshots of quinone cofactor biogenesis in bacterial copper amine oxidase., Kim M, Okajima T, Kishishita S, Yoshimura M, Kawamori A, Tanizawa K, Yamaguchi H, Nat Struct Biol. 2002 Aug;9(8):591-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12134140 12134140] | X-ray snapshots of quinone cofactor biogenesis in bacterial copper amine oxidase., Kim M, Okajima T, Kishishita S, Yoshimura M, Kawamori A, Tanizawa K, Yamaguchi H, Nat Struct Biol. 2002 Aug;9(8):591-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12134140 12134140] | ||
| - | [[Category: Amine oxidase (copper-containing)]] | ||
[[Category: Arthrobacter globiformis]] | [[Category: Arthrobacter globiformis]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: Yamaguchi, H.]] | [[Category: Yamaguchi, H.]] | ||
[[Category: Yoshimura, M.]] | [[Category: Yoshimura, M.]] | ||
| - | [[Category: | + | [[Category: Amine oxidase]] |
| - | [[Category: | + | [[Category: Biogenesis]] |
| - | [[Category: | + | [[Category: Copper]] |
| - | [[Category: | + | [[Category: Dah]] |
| - | [[Category: | + | [[Category: Freeze-trapp]] |
| - | [[Category: | + | [[Category: Intermediate]] |
| - | [[Category: | + | [[Category: Oxidoreductase]] |
| - | [[Category: | + | [[Category: Quinone cofactor]] |
| - | [[Category: | + | [[Category: Tpq]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:28:58 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 17:29, 2 May 2008
Crystal structure of copper amine oxidase from Arthrobacter globiformis: Early intermediate in topaquinone biogenesis
Overview
The quinone cofactor TPQ in copper amine oxidase is generated by posttranslational modification of an active site tyrosine residue. Using X-ray crystallography, we have probed the copper-dependent autooxidation process of TPQ in the enzyme from Arthrobacter globiformis. Apo enzyme crystals were anaerobically soaked with copper; the structure determined from this crystal provides a view of the initial state: the unmodified tyrosine coordinated to the bound copper. Exposure of the copper-bound crystals to oxygen led to the formation of freeze-trapped intermediates; structural analyses indicate that these intermediates contain dihydroxyphenylalanine quinone and trihydroxyphenylalanine. These are the first visualized intermediates during TPQ biogenesis in copper amine oxidase.
About this Structure
1IVV is a Single protein structure of sequence from Arthrobacter globiformis. Full crystallographic information is available from OCA.
Reference
X-ray snapshots of quinone cofactor biogenesis in bacterial copper amine oxidase., Kim M, Okajima T, Kishishita S, Yoshimura M, Kawamori A, Tanizawa K, Yamaguchi H, Nat Struct Biol. 2002 Aug;9(8):591-6. PMID:12134140 Page seeded by OCA on Fri May 2 20:28:58 2008
