4hc1

<StructureSection load='4hc1' size='340' side='right' caption='[[4hc1]], [[Resolution|resolution]] 2.87&Aring;' scene=''>

<table><tr><td colspan='2'>[[4hc1]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HC1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HC1 FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>

<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MADCAM1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hc1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hc1 OCA], [http://pdbe.org/4hc1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4hc1 RCSB], [http://www.ebi.ac.uk/pdbsum/4hc1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4hc1 ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/MADCA_HUMAN MADCA_HUMAN]] Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L-selectin binding.

[[Category: Human]]

[[Category: Lk3 transgenic mice]]

[[Category: Springer, T]]

[[Category: Yu, Y]]

[[Category: Zhu, J]]

[[Category: Immune system]]

[[Category: Rolling and firm adhesion]]