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4hex

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==A novel conformation of calmodulin==
==A novel conformation of calmodulin==
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<StructureSection load='4hex' size='340' side='right' caption='[[4hex]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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<StructureSection load='4hex' size='340' side='right'caption='[[4hex]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4hex]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HEX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HEX FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4hex]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HEX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HEX FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Cam ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hex FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hex OCA], [https://pdbe.org/4hex PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hex RCSB], [https://www.ebi.ac.uk/pdbsum/4hex PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hex ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hex FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hex OCA], [http://pdbe.org/4hex PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4hex RCSB], [http://www.ebi.ac.uk/pdbsum/4hex PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4hex ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CALM1_MOUSE CALM1_MOUSE] Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis. Is a regulator of voltage-dependent L-type calcium channels. Mediates calcium-dependent inactivation of CACNA1C. Positively regulates calcium-activated potassium channel activity of KCNN2. Forms a potassium channel complex with KCNQ1 and regulates electrophysiological activity of the channel via calcium-binding. Acts as a sensor to modulate the endoplasmic reticulum contacts with other organelles mediated by VMP1:ATP2A2 (By similarity).[UniProtKB:P0DP23]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4hex" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4hex" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Calmodulin 3D structures|Calmodulin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Lk3 transgenic mice]]
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[[Category: Large Structures]]
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[[Category: Chichili, V P.R]]
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[[Category: Mus musculus]]
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[[Category: Kumar, V]]
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[[Category: Chichili VPR]]
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[[Category: Sivaraman, J]]
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[[Category: Kumar V]]
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[[Category: Calcium binding]]
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[[Category: Sivaraman J]]
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[[Category: Calcium binding protein]]
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[[Category: Calcium signalling]]
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[[Category: Calmodulin]]
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[[Category: Ef-hand motif]]
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[[Category: Neurogranin]]
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[[Category: Neuromodulin]]
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[[Category: Novel conformation]]
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[[Category: Tran]]
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Revision as of 08:13, 3 November 2022

A novel conformation of calmodulin

PDB ID 4hex

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