1iwg
From Proteopedia
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[[Image:1iwg.jpg|left|200px]] | [[Image:1iwg.jpg|left|200px]] | ||
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'''Crystal structure of Bacterial Multidrug Efflux transporter AcrB''' | '''Crystal structure of Bacterial Multidrug Efflux transporter AcrB''' | ||
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[[Category: Yamaguchi, A.]] | [[Category: Yamaguchi, A.]] | ||
[[Category: Yamashita, E.]] | [[Category: Yamashita, E.]] | ||
| - | [[Category: | + | [[Category: Antiporter]] |
| - | [[Category: | + | [[Category: Drug resistance]] |
| - | [[Category: | + | [[Category: Membrane protein]] |
| - | [[Category: | + | [[Category: Multidrug efflux]] |
| - | [[Category: | + | [[Category: Transporter]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:30:19 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 17:30, 2 May 2008
Crystal structure of Bacterial Multidrug Efflux transporter AcrB
Overview
AcrB is a major multidrug exporter in Escherichia coli. It cooperates with a membrane fusion protein, AcrA, and an outer membrane channel, TolC. We have determined the crystal structure of AcrB at 3.5 A resolution. Three AcrB protomers are organized as a homotrimer in the shape of a jellyfish. Each protomer is composed of a transmembrane region 50 A thick and a 70 A protruding headpiece. The top of the headpiece opens like a funnel, where TolC might directly dock into AcrB. A pore formed by three alpha-helices connects the funnel with a central cavity located at the bottom of the headpiece. The cavity has three vestibules at the side of the headpiece which lead into the periplasm. In the transmembrane region, each protomer has twelve transmembrane alpha-helices. The structure implies that substrates translocated from the cell interior through the transmembrane region and from the periplasm through the vestibules are collected in the central cavity and then actively transported through the pore into the TolC tunnel.
About this Structure
1IWG is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.
Reference
Crystal structure of bacterial multidrug efflux transporter AcrB., Murakami S, Nakashima R, Yamashita E, Yamaguchi A, Nature. 2002 Oct 10;419(6907):587-93. PMID:12374972 Page seeded by OCA on Fri May 2 20:30:19 2008
