4hkf

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==Crystal structure of Danio rerio MEC-17 catalytic domain in complex with acetyl-CoA==
==Crystal structure of Danio rerio MEC-17 catalytic domain in complex with acetyl-CoA==
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<StructureSection load='4hkf' size='340' side='right' caption='[[4hkf]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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<StructureSection load='4hkf' size='340' side='right'caption='[[4hkf]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4hkf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Brachidanio_rerio Brachidanio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HKF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HKF FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4hkf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HKF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HKF FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hkf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hkf OCA], [https://pdbe.org/4hkf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hkf RCSB], [https://www.ebi.ac.uk/pdbsum/4hkf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hkf ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">atat1, mec17, si:ch211-152p11.5, zgc:65893 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7955 Brachidanio rerio])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alpha-tubulin_N-acetyltransferase Alpha-tubulin N-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.108 2.3.1.108] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hkf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hkf OCA], [http://pdbe.org/4hkf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4hkf RCSB], [http://www.ebi.ac.uk/pdbsum/4hkf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4hkf ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ATAT_DANRE ATAT_DANRE]] Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. May promote directional cell locomotion and chemotaxis (By similarity). May be required for normal sperm flagellar function (By similarity). May affect microtubule stability and regulate microtubule dynamics. May be involved in neuron development. Acetylates alpha-tubulin in neurons, but not in cilia.[HAMAP-Rule:MF_03130]<ref>PMID:20829795</ref>
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[https://www.uniprot.org/uniprot/ATAT_DANRE ATAT_DANRE] Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. May promote directional cell locomotion and chemotaxis (By similarity). May be required for normal sperm flagellar function (By similarity). May affect microtubule stability and regulate microtubule dynamics. May be involved in neuron development. Acetylates alpha-tubulin in neurons, but not in cilia.[HAMAP-Rule:MF_03130]<ref>PMID:20829795</ref>
==See Also==
==See Also==
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*[[Alpha-tubulin N-acetyltransferase|Alpha-tubulin N-acetyltransferase]]
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*[[Alpha-tubulin N-acetyltransferase 3D structures|Alpha-tubulin N-acetyltransferase 3D structures]]
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*[[Tubulin acetyltransferase|Tubulin acetyltransferase]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Alpha-tubulin N-acetyltransferase]]
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[[Category: Danio rerio]]
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[[Category: Brachidanio rerio]]
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[[Category: Large Structures]]
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[[Category: Ding, J]]
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[[Category: Ding J]]
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[[Category: Li, W]]
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[[Category: Li W]]
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[[Category: Sun, B]]
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[[Category: Sun B]]
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[[Category: Xu, S]]
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[[Category: Xu S]]
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[[Category: Zhang, T]]
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[[Category: Zhang T]]
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[[Category: Zhong, C]]
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[[Category: Zhong C]]
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[[Category: Acetyl-coa]]
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[[Category: Gnat]]
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[[Category: Gnat fold]]
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[[Category: Mec-17]]
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[[Category: Transferase]]
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[[Category: Tubulin acetyltransferase]]
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Revision as of 08:22, 3 November 2022

Crystal structure of Danio rerio MEC-17 catalytic domain in complex with acetyl-CoA

PDB ID 4hkf

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