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| | <StructureSection load='4hob' size='340' side='right'caption='[[4hob]], [[Resolution|resolution]] 1.76Å' scene=''> | | <StructureSection load='4hob' size='340' side='right'caption='[[4hob]], [[Resolution|resolution]] 1.76Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[4hob]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Carp_nephritis_and_gill_necrosis_virus Carp nephritis and gill necrosis virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HOB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HOB FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[4hob]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Cyprinid_herpesvirus_3 Cyprinid herpesvirus 3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HOB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HOB FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1j75|1j75]], [[1qbj|1qbj]], [[1oyi|1oyi]]</td></tr>
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hob FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hob OCA], [https://pdbe.org/4hob PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hob RCSB], [https://www.ebi.ac.uk/pdbsum/4hob PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hob ProSAT]</span></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">KHVJ122, ORF112 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=180230 Carp nephritis and gill necrosis virus])</td></tr>
| + | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hob FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hob OCA], [http://pdbe.org/4hob PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4hob RCSB], [http://www.ebi.ac.uk/pdbsum/4hob PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4hob ProSAT]</span></td></tr> | + | |
| | </table> | | </table> |
| | + | == Function == |
| | + | [https://www.uniprot.org/uniprot/A4FTK7_9VIRU A4FTK7_9VIRU] |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| | == Publication Abstract from PubMed == | | == Publication Abstract from PubMed == |
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| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Carp nephritis and gill necrosis virus]] | + | [[Category: Cyprinid herpesvirus 3]] |
| | [[Category: Large Structures]] | | [[Category: Large Structures]] |
| - | [[Category: Athanasiadis, A]] | + | [[Category: Athanasiadis A]] |
| - | [[Category: Figueiredo, D]] | + | [[Category: Figueiredo D]] |
| - | [[Category: Kus, K]] | + | [[Category: Kus K]] |
| - | [[Category: Paulo, L M]] | + | [[Category: Paulo LM]] |
| - | [[Category: Rosa, M de]]
| + | [[Category: Tome AR]] |
| - | [[Category: Tome, A R]] | + | [[Category: De Rosa M]] |
| - | [[Category: Dna and rna binding]] | + | |
| - | [[Category: Dna binding protein]]
| + | |
| - | [[Category: Domain swapping]]
| + | |
| - | [[Category: Z-dna binding domain]]
| + | |
| Structural highlights
Function
A4FTK7_9VIRU
Publication Abstract from PubMed
Zalpha domains are a subfamily of the winged helix-turn-helix domains sharing the unique ability to recognize CpG repeats in the left-handed Z-DNA conformation. In vertebrates, domains of this family are found exclusively in proteins that detect foreign nucleic acids and activate components of the antiviral interferon response. Moreover, poxviruses encode the Zalpha domain-containing protein E3L, a well-studied and potent inhibitor of interferon response. Here we describe a herpesvirus Zalpha-domain-containing protein (ORF112) from cyprinid herpesvirus 3. We demonstrate that ORF112 also binds CpG repeats in the left-handed conformation, and moreover, its structure at 1.75 A reveals the Zalpha fold found in ADAR1, DAI, PKZ, and E3L. Unlike other Zalpha domains, however, ORF112 forms a dimer through a unique domain-swapping mechanism. Thus, ORF112 may be considered a new member of the Z-domain family having DNA binding properties similar to those of the poxvirus E3L inhibitor of interferon response.
Crystal structure of a poxvirus-like zalpha domain from cyprinid herpesvirus 3.,Tome AR, Kus K, Correia S, Paulo LM, Zacarias S, de Rosa M, Figueiredo D, Parkhouse RM, Athanasiadis A J Virol. 2013 Apr;87(7):3998-4004. doi: 10.1128/JVI.03116-12. Epub 2013 Jan 30. PMID:23365431[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Tome AR, Kus K, Correia S, Paulo LM, Zacarias S, de Rosa M, Figueiredo D, Parkhouse RM, Athanasiadis A. Crystal structure of a poxvirus-like zalpha domain from cyprinid herpesvirus 3. J Virol. 2013 Apr;87(7):3998-4004. doi: 10.1128/JVI.03116-12. Epub 2013 Jan 30. PMID:23365431 doi:10.1128/JVI.03116-12
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