7o6t
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the polymerising VEL domain of VIN3 (R556D I575D mutant)== | |
| - | + | <StructureSection load='7o6t' size='340' side='right'caption='[[7o6t]], [[Resolution|resolution]] 2.02Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[7o6t]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7O6T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7O6T FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7o6t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7o6t OCA], [https://pdbe.org/7o6t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7o6t RCSB], [https://www.ebi.ac.uk/pdbsum/7o6t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7o6t ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/VIN3_ARATH VIN3_ARATH] Plays a central role in vernalization by mediating the initial transcriptional repression of the homeotic gene FLC, a floral repressor, after a cold treatment. However, due to its transient expression, it cannot maintain repression of FLC, which is then maintained by Polycomb Group complexes containing VRN2 throughout development. Required to deacetylate histones on the FLC promoter. Together with VIL1, required during vernalization for the modifications of FLC and FLM chromatin that are associated with an epigenetically silenced state (e.g. chromatin modifications, histone deacetylation, and trimethylated H3 'Lys-4' H3K4me3 and 'Lys-27' H3K27me3) and with acquisition of competence to flower.<ref>PMID:14712276</ref> <ref>PMID:17114575</ref> <ref>PMID:17174094</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Arabidopsis thaliana]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Bienz M]] | ||
| + | [[Category: Dean C]] | ||
| + | [[Category: Fiedler M]] | ||
| + | [[Category: Franco-Echevarria E]] | ||
Revision as of 07:16, 9 November 2022
Crystal structure of the polymerising VEL domain of VIN3 (R556D I575D mutant)
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