7rx7

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'''Unreleased structure'''
 
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The entry 7rx7 is ON HOLD until Paper Publication
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==Structure of METTL3-METTL14(R298P) mutant methyltransferase complex==
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<StructureSection load='7rx7' size='340' side='right'caption='[[7rx7]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
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Authors: Wang, P., Nam, Y.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7rx7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RX7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RX7 FirstGlance]. <br>
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Description: Structure of METTL3-METTL14(R298P) mutant methyltransferase complex
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rx7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rx7 OCA], [https://pdbe.org/7rx7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rx7 RCSB], [https://www.ebi.ac.uk/pdbsum/7rx7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rx7 ProSAT]</span></td></tr>
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[[Category: Unreleased Structures]]
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</table>
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[[Category: Nam, Y]]
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== Function ==
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[[Category: Wang, P]]
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[https://www.uniprot.org/uniprot/MTA70_HUMAN MTA70_HUMAN] N6-methyltransferase that methylates adenosine residues of some RNAs and acts as a regulator of the circadian clock, differentiation of embryonic stem cells and primary miRNA processing. N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in the efficiency of mRNA splicing, processing, translation efficiency, editing and mRNA stability (PubMed:22575960, PubMed:24284625, PubMed:25719671, PubMed:25799998, PubMed:26321680, PubMed:26593424, PubMed:9409616). M6A regulates the length of the circadian clock: acts as a early pace-setter in the circadian loop by putting mRNA production on a fast-track for facilitating nuclear processing, thereby providing an early point of control in setting the dynamics of the feedback loop (By similarity). M6A also acts as a regulator of mRNA stability: in embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization, promoting differentiation of ESCs (By similarity). M6A also takes place in other RNA molecules, such as primary miRNA (pri-miRNAs) (PubMed:25799998). Mediates methylation of pri-miRNAs, marking them for recognition and processing by DGCR8 (PubMed:25799998).[UniProtKB:Q8C3P7]<ref>PMID:22575960</ref> <ref>PMID:24284625</ref> <ref>PMID:25719671</ref> <ref>PMID:25799998</ref> <ref>PMID:26321680</ref> <ref>PMID:26593424</ref> <ref>PMID:9409616</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Nam Y]]
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[[Category: Wang P]]

Revision as of 07:19, 9 November 2022

Structure of METTL3-METTL14(R298P) mutant methyltransferase complex

PDB ID 7rx7

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