Structural highlights
Function
THTR_HUMAN Formation of iron-sulfur complexes, cyanide detoxification or modification of sulfur-containing enzymes. Other thiol compounds, besides cyanide, can act as sulfur ion acceptors. Also has weak mercaptopyruvate sulfurtransferase (MST) activity (By similarity). Together with MRPL18, acts as a mitochondrial import factor for the cytosolic 5S rRNA. Only the nascent unfolded cytoplasmic form is able to bind to the 5S rRNA.[1] [2]
References
- ↑ Smirnov A, Comte C, Mager-Heckel AM, Addis V, Krasheninnikov IA, Martin RP, Entelis N, Tarassov I. Mitochondrial enzyme rhodanese is essential for 5 S ribosomal RNA import into human mitochondria. J Biol Chem. 2010 Oct 1;285(40):30792-803. doi: 10.1074/jbc.M110.151183. Epub, 2010 Jul 27. PMID:20663881 doi:http://dx.doi.org/10.1074/jbc.M110.151183
- ↑ Smirnov A, Entelis N, Martin RP, Tarassov I. Biological significance of 5S rRNA import into human mitochondria: role of ribosomal protein MRP-L18. Genes Dev. 2011 Jun 15;25(12):1289-305. doi: 10.1101/gad.624711. PMID:21685364 doi:http://dx.doi.org/10.1101/gad.624711
