4hup

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<StructureSection load='4hup' size='340' side='right'caption='[[4hup]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
<StructureSection load='4hup' size='340' side='right'caption='[[4hup]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4hup]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Castor_bean Castor bean]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HUP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HUP FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4hup]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Ricinus_communis Ricinus communis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HUP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HUP FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=19M:(2S)-2-[[(2S)-2-[2-[(2-AZANYL-4-OXIDANYLIDENE-1H-PTERIDIN-7-YL)CARBONYLAMINO]ETHANOYLAMINO]-3-PHENYL-PROPANOYL]AMINO]-3-PHENYL-PROPANOIC+ACID'>19M</scene>, <scene name='pdbligand=MLA:MALONIC+ACID'>MLA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=19M:(2S)-2-[[(2S)-2-[2-[(2-AZANYL-4-OXIDANYLIDENE-1H-PTERIDIN-7-YL)CARBONYLAMINO]ETHANOYLAMINO]-3-PHENYL-PROPANOYL]AMINO]-3-PHENYL-PROPANOIC+ACID'>19M</scene>, <scene name='pdbligand=MLA:MALONIC+ACID'>MLA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1rtc|1rtc]], [[1ift|1ift]], [[1br6|1br6]], [[1px8|1px8]], [[4esi|4esi]], [[4huo|4huo]], [[4hv7|4hv7]], [[4hv3|4hv3]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hup FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hup OCA], [https://pdbe.org/4hup PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hup RCSB], [https://www.ebi.ac.uk/pdbsum/4hup PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hup ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/rRNA_N-glycosylase rRNA N-glycosylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.22 3.2.2.22] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hup FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hup OCA], [http://pdbe.org/4hup PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4hup RCSB], [http://www.ebi.ac.uk/pdbsum/4hup PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4hup ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/RICI_RICCO RICI_RICCO]] Ricin is highly toxic to animal cells and to a lesser extent to plant cells. The A chain acts as a glycosidase that removes a specific adenine residue from an exposed loop of the 28S rRNA (A4324 in mammals), leading to rRNA breakage. As this loop is involved in elongation factor binding, modified ribosomes are catalytically inactive and unable to support protein synthesis. The A chain can inactivate a few thousand ribosomes per minute, faster than the cell can make new ones. Therefore a single A chain molecule can kill an animal cell. The B chain binds to beta-D-galactopyranoside moieties on cell surface glycoproteins and glycolipids and facilitates the entry into the cell of the A chain; B chains are also responsible for cell agglutination (Lectin activity).
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[https://www.uniprot.org/uniprot/RICI_RICCO RICI_RICCO] Ricin is highly toxic to animal cells and to a lesser extent to plant cells. The A chain acts as a glycosidase that removes a specific adenine residue from an exposed loop of the 28S rRNA (A4324 in mammals), leading to rRNA breakage. As this loop is involved in elongation factor binding, modified ribosomes are catalytically inactive and unable to support protein synthesis. The A chain can inactivate a few thousand ribosomes per minute, faster than the cell can make new ones. Therefore a single A chain molecule can kill an animal cell. The B chain binds to beta-D-galactopyranoside moieties on cell surface glycoproteins and glycolipids and facilitates the entry into the cell of the A chain; B chains are also responsible for cell agglutination (Lectin activity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Ricin|Ricin]]
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*[[Ricin 3D structures|Ricin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Castor bean]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: RRNA N-glycosylase]]
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[[Category: Ricinus communis]]
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[[Category: Anslyn, E V]]
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[[Category: Anslyn EV]]
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[[Category: Jasheway, K R]]
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[[Category: Jasheway KR]]
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[[Category: Manzano, L A]]
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[[Category: Manzano LA]]
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[[Category: Monzingo, A F]]
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[[Category: Monzingo AF]]
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[[Category: Pruet, J M]]
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[[Category: Pruet JM]]
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[[Category: Robertus, J D]]
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[[Category: Robertus JD]]
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[[Category: Saito, R]]
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[[Category: Saito R]]
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[[Category: Wiget, P A]]
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[[Category: Wiget PA]]
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[[Category: Hydrolase]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: N-glycosidase]]
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[[Category: Protein-ligand complex]]
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[[Category: Pterin]]
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[[Category: Ribosome-inactivating protein]]
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[[Category: Ricin]]
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[[Category: Toxin]]
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Revision as of 08:16, 9 November 2022

Structure of ricin A chain bound with N-(N-(pterin-7-yl)carbonylglycyl)-L-phenylalanyl)-L-phenylalanine

PDB ID 4hup

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